Browse > Article

Effects of Cortical Activation upon Mechanical Force-Mediated Changes in the OPG and RANKL Levels in Gingival Crevicular Fluid  

Yu, Nam-Hyun (Department of Orthodontics, Institute of Oral Biosciences and BK 21 program, School of Dentistry, Chonbuk National University)
Kwak, So-Yeong (Department of Orthodontics, Institute of Oral Biosciences and BK 21 program, School of Dentistry, Chonbuk National University)
Hong, So-Yeon (Department of Orthodontics, Institute of Oral Biosciences and BK 21 program, School of Dentistry, Chonbuk National University)
Kim, Jong-Ghee (Department of Orthodontics, Institute of Oral Biosciences and BK 21 program, School of Dentistry, Chonbuk National University)
Jeon, Young-Mi (Department of Orthodontics, Institute of Oral Biosciences and BK 21 program, School of Dentistry, Chonbuk National University)
Lee, Jeong-Chae (Research Center of Bioactive Materials, Chonbuk National University)
Publication Information
International Journal of Oral Biology / v.34, no.4, 2009 , pp. 199-203 More about this Journal
Abstract
This study investigated whether orthodontic force influences the production of osteoprotegerin (OPG) and receptor activator of nuclear factor-kappa B ligand (RANKL) in vivo, both of which are affected by cortical activation. Mechanical force was applied to the maxillary premolars of orthodontic patients by fitting the transpalatal arch prior to cortical activation of the gingival tissue. Gingival crevicular fluid (GCF) samples were then collected from each patient using paper strips before and after 1, 3, 7 or 14 days of treatment. The OPG and RANKL levels in the GCF were determined by enzyme-linked immunosorbent assays. The levels of OPG were significantly increased after 1 day of fitting the appliance and decreased to basal levels at 3 days after fitting. In contrast, the RANKL levels were dramatically decreased at 1 day after fitting, but recovered to those of the untreated control at 3 days after the force application. The force-mediated changes in the OPG and RANKL levels of the GCF were unaffected by cortical activation during these experimental periods. Collectively, these results suggest that an acute and severe change between the OPG and RANKL levels plays an important role in stimulating the cellular responses required for alveolar bone remodeling by orthodontic treatment.
Keywords
cortical activation; osteoprotegerin; RANKL; gingival crevicular fluid;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Bachmann MF, Wong BR, Josien R, Steinman RM, Oxenius A, Choi Y. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. J Exp Med. 1999;189:1025-31   DOI   ScienceOn
2 Choi YS, Jang HS, Lee DS, Kim HJ, Park JT, Bae HS, Park JC. The effect of UNCL inactivation on the expression of mechanical stress related genes in cultured human PDL fibroblasts. Int J Oral Biol. 2008;33:51-8   과학기술학회마을   ScienceOn
3 Cho KW, Cho-SW, Oh CO, Ryu YK, Ohshima H, Jung HS. The effect of cortical activation on orthodontic tooth movement. Oral Disease. 2007;13:314-9   DOI   ScienceOn
4 Kawasaki K, Takahashi T, Yamaguchi M, Kasai. Effects of aging on RANKL and OPG levels in gingival crevicular fluid during orthodontic tooth movement. Orthod Craniofacial Res. 2006;9:137-42   DOI   ScienceOn
5 Masella RS, Meister M. Current concepts in the biology of mechanical tooth movement. Am J Orthod Dentofacial Orthop. 2006;129:458-68   DOI   ScienceOn
6 Nakao K, Goto T, Gunjigake K, Konoo T, Kobayashi S, Yamaguchi K. Intermittent force induces high RANKL expression in human periodontal ligament cells. J Dent Res. 2007;86:623-28   DOI   ScienceOn
7 Udagawa N, Takahashi N, Jimi E, Matsuzaki K, Tsurukai T, Itoh K. Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activation of NF-kappa B ligand. Bone. 1999;25:517-23   DOI   ScienceOn
8 Anholm JM, Crites DA, Hoff R, Rathbun WE. Corticotomy facilitated orthodontics. CDA J. 1986;14:7-11
9 Ko SH, Lee JH, Kim SH. The effects of mechanical strain on bone cell proliferation and recruitment induced by osteocytes. Int J Oral Biol. 2008;33:179-86   ScienceOn
10 Gantes B, Rathbun E, Anholm M. Effects on the periodontium following corticotomy-facilitated orthodontics. Case reports. J Periodontol. 1990;61:234-38   DOI
11 Griffiths GS, Moulson AM, Petrie A, James IT. Evaluation of osteocalcin and pyridinium crosslinks of bone collagen as markers of bone turnover in gingival crevicular fluid during different stages of orthodontic treatment. J Clin Periodontal. 1998;25:492-8   DOI   ScienceOn
12 Katagiri T, Takahashi N. Regulatory mechanism of osteoblast and osteoclast differentiation. Periodontol. 2000;41:48-72   DOI   ScienceOn
13 Rygh P. Ultrastructual change in tension zones of rat molar periodontium incident to orthodontic tooth movement. Am J Orthod. 1976;70:269-81   DOI   ScienceOn
14 Yamaguchi K, Kinosaki M, Goto M, Kobayashi F, Tsuda E, Morinaga T. Characterization of structural domains of human osteoclastogenesis inhibitory factor. J Biol Chem. 1998;273:5117-23   DOI   ScienceOn
15 Wilcko WM, Bouquot JE, Ferguson DJ, Wilcko T. Rapid orthodontic decrowding with alveolar augmentation: case report. World J Orthod. 2003;4:197-205
16 Davidovitch Z, Nicilay OF, Ngan PW, Shanfeld JL. Neurotransmitters, cytokines, and the control of alveolar bone remodeling in orthodontics. Dent Clin North Am. 1988;32:411-35
17 Sandy JR, Farndale RW, Meikle MC. Recent advantages in understating mechanically induced bone remodeling and their relevance to orthodontic theory and practice. Am J Orthod Dentofacial Orthop. 1993;103:212-22   DOI   ScienceOn
18 Frost HM. The regional accelerated phenomenon. Orthop Clin North Am. 1981;12:725-6
19 Frost HM. The biology of fracture healing. An overview for clinicians. Part I. Clin Orthop Relat Res. 1989;248:283-93   ScienceOn
20 Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev. 1999;20:345-57   DOI   ScienceOn
21 Kook SH, Son YO, Hwang JM, Kim EM, Lee CB, Jeon YM, Kim JG, Lee JC. Mechanical force inhibits osteoclastogenic potential of human periodontal ligament fibroblasts through OPG production and ERK-mediated signaling. J Cell Biochem. 2009;106:1010-19   DOI   ScienceOn
22 Nishijima Y, Yamaguchi M, Kojima T, Aihara N, Nakajima R, Kasai K. Level of RANKL and OPG in gingival crevicular fluid during orthodontic tooth movement and effect of compression force on releases from periodontal ligament cells in vitro. Orthod Craniofac Res. 2006;9:63-70   DOI   ScienceOn
23 Lacey DL, Tan HL, Lu J, Kaufman S, Van G, Qiu W, Rattan A, Scully S, Fletcher F, Juan T, Kelley M, Burgess TL, Boyle WJ, Polverino AJ. Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am J Pathol. 2000;157:435-48   DOI   ScienceOn
24 Wilcko WM, Wilcko T, Bouquot JE, Ferguson DJ. Rapid orthodontics with alveolar reshaping: two case reports of decrowding. Int J Periodontics Restorative Dent. 2001;21:9-19   ScienceOn
25 Garlet TP, Coelho U, Silva JS, Garlet GP. Cytokine expression pattern in compression and tension sides of the periodontal ligament during orthodontic tooth movement in humans. Eur J Oral Sci. 2007;115:355-62   DOI   ScienceOn
26 Burgess TL, Qian Y, Kaufman S, Ring BD, Van G, Capparelli C. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J Cell Biol. 1999;145:527-38   DOI   ScienceOn
27 McColloch CAG, Nemeth E, Lowenberg B, Melcher AH. Paravascular cells in endosteal spaces of alveolar bone contribute to periodontal ligament cell populations. Anat Rec. 1987;219:233-42   DOI   ScienceOn
28 Yaffe A, Fine N, Binderman I. Regional accelerated phenomenon in the mandible following mucoperiosteal flap surgery. J Periodontol. 1994;65:79-83   DOI   ScienceOn
29 Canlis E, McCarthy TL, Centrella M. Growth factors and cytokines in bone cell metabolism. Am Rev Med. 1991;42:17-24   DOI   ScienceOn