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http://dx.doi.org/10.5125/jkaoms.2022.48.2.71

Use of stem cells in bone regeneration in cleft palate patients: review and recommendations  

Amiri, Mohammad Amin (Student Research Committee, Shiraz University of Medical Sciences)
Lavaee, Fatemeh (Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences)
Danesteh, Hossein (Department of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.48, no.2, 2022 , pp. 71-78 More about this Journal
Abstract
This study was conducted to review the efficacy of different sources of stem cells in bone regeneration of cleft palate patients. The majority of previous studies focused on the transplantation of bone marrow mesenchymal stem cells. However, other sources of stem cells have also gained considerable attention, and dental stem cells have shown especially favorable outcomes. Additionally, approaches that apply the co-culture and co-transplantation of stem cells have shown promising results. The use of different types of stem cells, based on their accessibility and efficacy in bone regeneration, is a promising method in cleft palate bone regeneration. In this regard, dental stem cells may be an ideal choice due to their efficacy and accessibility. In conclusion, stem cells, despite the lengthy procedures required for culture and preparation, are a suitable alternative to conventional bone grafting techniques.
Keywords
Cleft palate; Tissue engineering; Bone regeneration; Craniofacial abnormalities; Stem cells;
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