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http://dx.doi.org/10.5125/jkaoms.2020.46.5.348

High grade carcinoma ex pleomorphic adenoma of parotid gland: a case report  

Kim, Ji-Kwan (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University)
Kim, Moon-Young (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University)
Choi, Seung-Kyu (Department of Pathology, Dankook University College of Medicine)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.46, no.5, 2020 , pp. 348-352 More about this Journal
Abstract
Pleomorphic adenoma is the most prevalent benign tumor of the parotid gland, and shows potential malignancy. Carcinoma ex pleomorphic adenoma (CXPA) can occur in 3%-15% of pleomorphic adenoma cases. Owing to its clinical similarity to benign tumors, critical information related to CXPA can be easily overlooked, leading to frequent misdiagnosis of the condition. In this article, we report a rare case of CXPA found in the 55-year-old male patient with characteristic clinical, radiographic, and histological features, and subsequent treatment.
Keywords
Pleomorphic adenoma; Carcinoma; Cancer of the head; Parotid gland;
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1 Gnepp DR, Brandwein-Gensler MS, El-Naggar AK, Nagao T. Carcinoma ex pleomorphic adenoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D, eds. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005:242-3.
2 Spiro RH, Huvos AG, Strong EW. Malignant mixed tumor of salivary origin: a clinicopathologic study of 146 cases. Cancer 1977;39:388-96. https://doi.org/10.1002/1097-0142(197702)39:2<388::aid-cncr2820390204>3.0.co;2-d   DOI
3 Antony J, Gopalan V, Smith RA, Lam AK. Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data. Head Neck Pathol 2012;6:1-9. https://doi.org/10.1007/s12105-011-0281-z
4 Beahrs OH, Woolner LB, Kirklin JW, Devine KD. Carcinomatous transformation of mixed tumors of the parotid gland. AMA Arch Surg 1957;75:605-13; discussion 613-4. https://doi.org/10.1001/archsurg.1957.01280160115015   DOI
5 Seifert G. Histopathology of malignant salivary gland tumours. Eur J Cancer B Oral Oncol 1992;28B:49-56. https://doi.org/10.1016/0964-1955(92)90013-q   DOI
6 Olsen KD, Lewis JE. Carcinoma ex pleomorphic adenoma: a clinicopathologic review. Head Neck 2001;23:705-12. https://doi.org/10.1002/hed.1100   DOI
7 Kato H, Kanematsu M, Mizuta K, Ito Y, Hirose Y. Carcinoma ex pleomorphic adenoma of the parotid gland: radiologic-pathologic correlation with MR imaging including diffusion-weighted imaging. AJNR Am J Neuroradiol 2008;29:865-7. https://doi.org/10.3174/ajnr.A0974   DOI
8 Lewis JE, Olsen KD, Sebo TJ. Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. Hum Pathol 2001;32:596-604. https://doi.org/10.1053/hupa.2001.25000   DOI
9 Altemani A, Martins MT, Freitas L, Soares F, Araujo NS, Araujo VC. Carcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression. Histopathology 2005;46:635-41. https://doi.org/10.1111/j.1365-2559.2005.02157.x   DOI
10 Nouraei SA, Hope KL, Kelly CG, McLean NR, Soames JV. Carcinoma ex benign pleomorphic adenoma of the parotid gland. Plast Reconstr Surg 2005;116:1206-13. https://doi.org/10.1097/01.prs.0000181654.68120.0f   DOI
11 Chen AM, Garcia J, Bucci MK, Quivey JM, Eisele DW. The role of postoperative radiation therapy in carcinoma ex pleomorphic adenoma of the parotid gland. Int J Radiat Oncol Biol Phys 2007;67:138-43. https://doi.org/10.1016/j.ijrobp.2006.07.1380   DOI
12 Thompson L. World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Ear Nose Throat J 2006;85:74.   DOI
13 Gnepp DR. Malignant mixed tumors of the salivary glands: a review. Pathol Annu 1993;28 Pt 1:279-328.
14 Tortoledo ME, Luna MA, Batsakis JG. Carcinomas ex pleomorphic adenoma and malignant mixed tumors. Histomorphologic indexes. Arch Otolaryngol 1984;110:172-6. https://doi.org/10.1001/archotol.1984.00800290036008   DOI