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http://dx.doi.org/10.5125/jkaoms.2020.46.4.282

Undifferentiated pleomorphic sarcoma of the mandible  

Benites, Bernar Monteiro (Department of Oral Medicine, Hospital Sirio Libanes)
Miranda-Silva, Wanessa (Department of Oral Medicine, Hospital Sirio Libanes)
Fonseca, Felipe Paiva (Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais)
Oliveira, Claudia Regina Gomes Cardim Mendes de (Department of Pathology, Hospital Sirio Libanes)
Fregnani, Eduardo Rodrigues (Department of Oral Medicine, Hospital Sirio Libanes)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.46, no.4, 2020 , pp. 282-287 More about this Journal
Abstract
Undifferentiated pleomorphic sarcoma (UPS) is a high-grade neoplasm that is usually located in the extremities and retroperitoneum. In the past, UPS was considered the most common soft tissue sarcoma in adults; due to improvements in diagnostic techniques, most cases have been reclassified as other lineage-specific tumors. Gnathic bones are rarely affected, and the clinicopathological characteristics of this neoplasm when diagnosed in the jaw remain to be better described. In this report, we present a rare case of mandibular UPS affecting an 88-year-old female who demonstrated a painful swelling on the right side of the mandible that was accompanied by a pathological fracture. Microscopic examination revealed a pleomorphic spindle-cell neoplasm with mitotic figures and necrosis. The patient underwent surgery and adjuvant radiotherapy but experienced metastasis after 12 months of follow-up and died. Diagnosis of UPS is challenging, and oral pathologists must be aware of this entity when dealing with aggressive undifferentiated neoplasms.
Keywords
Soft tissue sarcoma; Pleomorphic sarcoma; Malignant fibrous histiocytoma; Oral cavity; Mandible;
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