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http://dx.doi.org/10.5125/jkaoms.2020.46.3.197

FK506 immunosuppression for submandibular salivary gland allotransplantation in rabbit  

Almansoori, Akram Abdo (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University)
Khentii, Namuun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University)
Ju, Kyung Won (Clinical Translational Research Center for Dental Science, Seoul National University Dental Hospital)
Kim, Bongju (Clinical Translational Research Center for Dental Science, Seoul National University Dental Hospital)
Kim, Soung Min (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University)
Lee, Jong-Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.46, no.3, 2020 , pp. 197-203 More about this Journal
Abstract
Objectives: We compared the outcomes of two different doses of FK506 (tacrolimus) for immunosuppression in submandibular salivary gland (SMG) allotransplantation. Materials and Methods: Three SMG allotransplantation groups were established (n=6 per group) as follows: allograft rejection control (Allo-Ctrl), low dose (0.08 mg/kg) of FK506 (FK506-L), and high dose (0.16 mg/kg) of FK506 (FK506-H). Allograft survival and rejection were assessed by clinical observation, interleukin-2 levels as determined by enzyme-linked immunosorbent assay, blood sampling for complete blood count (CBC), and histological evaluation. Results: Body weight and anorexia were higher in the FK506-H group but without a significant difference compared with the FK506-L population. CBC revealed a non-significantly reduced number of changes in the FK506-L group. Four glands in the FK506-H group and two glands in the FK506- L group were viable and functioning post-transplantation. Conclusion: The survival rate of allotransplanted glands was higher in conjunction with the high dose of 0.16 mg/kg of FK506, with no major difference in the side-effect profile when compared with the low dose of 0.08 mg/kg short-term outcomes.
Keywords
Submandibular salivary gland; Allotransplantation; Immunosuppression; FK506; Tacrolimus;
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