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http://dx.doi.org/10.5125/jkaoms.2020.46.2.99

Analyzing the factors that influence occult metastasis in oral tongue cancer  

Shin, Jung-Hyun (Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University)
Yoon, Hye-Jung (Department of Oral Pathology, Dental Research Institute, School of Dentistry, Seoul National University)
Kim, Soung-Min (Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University)
Lee, Jong-Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University)
Myoung, Hoon (Department of Oral and Maxillofacial Surgery, School of Dentistry and Dental Research Institute, Seoul National University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.46, no.2, 2020 , pp. 99-107 More about this Journal
Abstract
Objectives: We accessed the various clinico-histopathological factors, and their association with occult metastasis (OM) in oral tongue squamous cell carcinoma (OTSCC). Materials and Methods: One hundred-nine patients with OTSCC were divided into the elective neck dissection (END) group and the watchful waiting (WW) group. Age, sex, T-stage, depth of invasion and differentiation were evaluated to determine the correlation between clinico-histopathological factors and OM. For immunohistochemical analysis, paraffin-embedded blocks of 41 OTSCC specimens were examined with antibodies (VEGF-c, c-Met, and ROR1). Results: The group with tumor thickness of oral tongue cancer ≥3 mm had higher incidence of OM than those with a thickness of <3 mm. The depth of invasion was statistically correlated with OM (P=0.022). Immunohistochemical analysis showed that high expression of VEGF-c (P=0.043), c-Met (P=0.009), and ROR-1 (P=0.003) were statistically correlated with OM. Conclusion: The analysis of these clinico-histopathological and immunohistochemical factors can help to determine neck dissection in clinically negative (cN0) patients.
Keywords
Tongue cancer; Elective neck dissection; Watchful waiting; Occult metastasis; Immunohistochemistry;
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