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http://dx.doi.org/10.5125/jkaoms.2018.44.2.66

Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics  

Min, Seung-Ki (Oral Oncology Clinic, Research Institute and Hospital, National Cancer Center)
Jeong, Joo Hee (Oral Oncology Clinic, Research Institute and Hospital, National Cancer Center)
Ahn, Kang-Min (Department of Oral and Maxillofacial Surgery, Asan Medical Center, University of Ulsan College of Medicine)
Yoo, Chong Woo (Department of Pathology, Research Institute and Hospital, National Cancer Center)
Park, Joo Yong (Oral Oncology Clinic, Research Institute and Hospital, National Cancer Center)
Choi, Sung Weon (Oral Oncology Clinic, Research Institute and Hospital, National Cancer Center)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.44, no.2, 2018 , pp. 66-72 More about this Journal
Abstract
Objectives: Desmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanotic benign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review. Materials and Methods: We analyzed 19 desmoplastic melanoma cases reported in the literature and added our experience. Data on clinical, histopathology, treatment, and survival were retrieved and analyzed. Survival analysis was by the Kaplan-Meier method. Results: Initial clinical and histopathological features were indistinctive, and a definite diagnosis of desmoplastic melanoma at initial assessment was possible in only 23.5% of cases. Among tests, immunohistochemical studies for S-100 and vimentin were all positive. The 5-year disease-free survival rate for oral desmoplastic melanoma was 0%, and the 5-year overall survival rate was 55.0%. Conclusion: Oral desmoplastic melanoma has a high percentage of initial misdiagnosis and propensity for local recurrence. Thus, careful initial diagnosis and adequate surgery may result in improved overall survival.
Keywords
Oral desmoplastic melanoma; Diagnosis; Recurrence; Survival;
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1 Prasad ML, Patel SG, Busam KJ. Primary mucosal desmoplastic melanoma of the head and neck. Head Neck 2004;26:373-7.   DOI
2 Choi G, Kim JW, Nam SY, Cho KJ. Primary mucosal desmoplastic melanoma of gingiva: a case report. Korean J Pathol 2006;40:456-60.
3 Ramani P, Chandrasekar T, Narayanan V, Anuja N, Karthikeyan R, Reddy S, et al. Desmoplastic malignant melanoma of alveolus: a rare entity. Oral Oncol Extra 2006;42:291-4.   DOI
4 Koseoglu RD, Aladag I, Sezer E, Ozkan N. Primary mucosal desmoplastic melanoma of the gingiva. Turk J Med Sci 2009;39:483-90.
5 Jou A, Miranda FV, Oliveira MG, Martins MD, Rados PV, Filho MS. Oral desmoplastic melanoma mimicking inflammatory hyperplasia. Gerodontology 2012;29:e1163-7.   DOI
6 Smyth EC, Flavin M, Pulitzer MP, Gardner GJ, Costantino PD, Chi DS, et al. Treatment of locally recurrent mucosal melanoma with topical imiquimod. J Clin Oncol 2011;29:e809-11.   DOI
7 Belgaumi UI, Shetty P, Shirlal S. Oral malignant melanoma: a case report of an unusual clinical and histologic presentation. Dent Res J (Isfahan) 2013;10:404-7.
8 R: a language and environment for statistical computing [Internet]. Vienna: R Foundation for Statistical Computing. Available from: http://www.R-project.org/.
9 Sortino-Rachou AM, Cancela Mde C, Voti L, Curado MP. Primary oral melanoma: population-based incidence. Oral Oncol 2009;45:254-8.   DOI
10 Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1998;83:1664-78.   DOI
11 Hicks MJ, Flaitz CM. Oral mucosal melanoma: epidemiology and pathobiology. Oral Oncol 2000;36:152-69.   DOI
12 Paulo LF, Servato JP, Rosa RR, Oliveira MT, Faria PR, Silva SJ, et al. Primary amelanotic mucosal melanoma of the oronasal region: report of two new cases and literature review. Oral Maxillofac Surg 2015;19:333-9.   DOI
13 Conley J, Lattes R, Orr W. Desmoplastic malignant melanoma (a rare variant of spindle cell melanoma). Cancer 1971;28:914-36.   DOI
14 Magro CM, Crowson AN, Mihm MC. Unusual variants of malignant melanoma. Mod Pathol 2006;19 Suppl 2:S41-70.   DOI
15 Batsakis JG, Bauer R, Regezi JA, Campbell T. Desmoplastic melanoma of the maxillary alveolus. J Oral Surg 1979;37:107-9.
16 Feng Z, Wu X, Chen V, Velie E, Zhang Z. Incidence and survival of desmoplastic melanoma in the United States, 1992-2007. J Cutan Pathol 2011;38:616-24.   DOI
17 Edge S, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. AJCC cancer staging manual. 7th ed. New York: Springer; 2010.
18 Kim UK, Heo JH, Hwang DS, Kim YD, Shin SH, Kim JR, et al. Clinical study on malignant melanoma in oral cavity. J Korean Assoc Oral Maxillofac Surg 2008;34:611-5.
19 Chen JH, Meng CL, Chao LS, Tu CN, Shyu KW. Desmoplastic amelanotic melanoma of palate: a case report with immunohistochemistry and electron microscopic studies. Zhonghua Ya Yi Xue Hui Za Zhi 1989;8:80-9.
20 Jain S, Allen PW. Desmoplastic malignant melanoma and its variants. A study of 45 cases. Am J Surg Pathol 1989;13:358-73.   DOI
21 Kurihara K, Sanada E, Yasuda S, Yamasaki H. Desmoplastic malignant melanoma of the gingiva. Oral Surg Oral Med Oral Pathol 1992;74:201-5.   DOI
22 Devaraj VS, Moss AL, Briggs JC. Desmoplastic melanoma: a clinico-pathological review. Br J Plast Surg 1992;45:595-8.   DOI
23 Manganaro AM, Hammond HL, Dalton MJ, Williams TP. Oral melanoma: case reports and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;80:670-6.   DOI
24 Ueta E, Miki T, Osaki T, Iwata J, Sonobe H. Desmoplastic malignant melanoma of the gingiva: case report and review of the literature. Eur J Cancer B Oral Oncol 1996;32B:423-7.
25 Kavanagh BD, Campbell RL, Patterson JW, O'Neill RL, Cardinale RM, Kaugars GE. Desmoplastic malignant melanoma of the palatal alveolar mucosa: sustained disease-free survival after surgery and postoperative radiotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89:465-70.   DOI
26 Kilpatrick SE, White WL, Browne JD. Desmoplastic malignant melanoma of the oral mucosa. An underrecognized diagnostic pitfall. Cancer 1996;78:383-9.   DOI