Browse > Article
http://dx.doi.org/10.5125/jkaoms.2017.43.4.272

A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report  

Viviano, Massimo (Department of Medical Biotechnologies, Dentistry Clinic)
Addamo, Alessandra (Department of Medical Biotechnologies, Dentistry Clinic)
Cocca, Serena (Department of Medicine, Surgery and Neurosciences, ENT Clinic, University of Siena)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.43, no.4, 2017 , pp. 272-275 More about this Journal
Abstract
Bisphosphonates are drugs used to treat osteoclast-mediated bone resorption, including osteoporosis, Paget disease, multiple myeloma, cancer-related osteolysis, and malignant hypercalcemia. The use of these drugs has increased in recent years as have their complications, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), which more frequently affects the mandible. Here we report a case of BRONJ with a particularly unfavorable course due to cervical inflammation that developed into necrotizing fasciitis, followed by multiorgan involvement leading to septic shock and death.
Keywords
Bisphosphonate-associated osteonecrosis of the jaw; Sepsis; Necrotizing fasciitis; Jaw fractures;
Citations & Related Records
연도 인용수 순위
  • Reference
1 de Groen PC, Lubbe DF, Hirsch LJ, Daifotis A, Stephenson W, Freedholm D, et al. Esophagitis associated with the use of alendronate. N Engl J Med 1996;335:1016-21.   DOI
2 Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 2003;61:1115-7.   DOI
3 Marx RE, Sawatari Y, Fortin M, Broumand V. Bisphosphonateinduced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg 2005;63:1567-75.   DOI
4 Woo SB, Hellstein JW, Kalmar JR. Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. Ann Intern Med 2006;144:753-61.   DOI
5 Otto S, Schreyer C, Hafner S, Mast G, Ehrenfeld M, Sturzenbaum S, et al. Bisphosphonate-related osteonecrosis of the jaws: characteristics, risk factors, clinical features, localization and impact on oncological treatment. J Craniomaxillofac Surg 2012;40:303-9.   DOI
6 Greinwald JH Jr, Wilson JF, Haggerty PG. Peritonsillar abscess: an unlikely cause of necrotizing fasciitis. Ann Otol Rhinol Laryngol 1995;104:133-7.   DOI
7 Lee SH, Chan RC, Chang SS, Tan YL, Chang KH, Lee MC, et al. Use of bisphosphonates and the risk of osteonecrosis among cancer patients: a systemic review and meta-analysis of the observational studies. Support Care Cancer 2014;22:553-60.   DOI
8 Ruggiero SL, Woo SB. Biophosphonate-related osteonecrosis of the jaws. Dent Clin North Am 2008;52:111-28, ix.   DOI
9 Tsitsilonis S, Druschel C, Wichlas F, Haas NP, Schwabe P, Bail HJ, et al. Necrotizing fasciitis: is the bacterial spectrum changing? Langenbecks Arch Surg 2013;398:153-9.   DOI
10 Tung-Yiu W, Jehn-Shyun H, Ching-Hung C, Hung-An C. Cervical necrotizing fasciitis of odontogenic origin: a report of 11 cases. J Oral Maxillofac Surg 2000;58:1347-52.   DOI
11 Lorenzini G, Picciotti M, Di Vece L, Pepponi E, Brindisi L, Vessio V, et al. Cervical necrotizing fasciitis of odontogenic origin involving the temporal region--a case report. J Craniomaxillofac Surg 2011;39:570-3.   DOI
12 Roberson JB, Harper JL, Jauch EC. Mortality associated with cervicofacial necrotizing fasciitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82:264-7.   DOI
13 Kaehling Ch, Streckbein P, Schmermund D, Henrich M, Burchert D, Gattenloehner S, et al. Lethal cervical abscess following bisphosphonate related osteonecrosis of the jaw. J Craniomaxillofac Surg 2014;42:1203-6.   DOI