Browse > Article
http://dx.doi.org/10.5125/jkaoms.2017.43.3.160

Platelet rich fibrin in the management of established dry socket  

Chakravarthi, Srinivas (Department of Oral and Maxillofacial Surgery, Sibar Institute of Dental Sciences)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.43, no.3, 2017 , pp. 160-165 More about this Journal
Abstract
Objectives: Dry socket may occur secondary to the removal of any tooth. However, most dry socket cases develop in the third molar region. Dry socket is multifactorial in nature and has been treated using various modalities with varying success rates. This study assessed the efficacy of platelet rich fibrin (PRF) in established dry socket. Materials and Methods: Ten patients of either sex aged from 41 to 64 years with established dry socket according to established criteria were treated using PRF. Evaluation was performed by observing the reduction of pain using visual analogue scale, analgesic tablet use over the follow-up period, and healing parameters. Results: Pain was reduced on the first day in all patients with decreased analgesic use. Pain was drastically reduced during follow-up on the first, second, third, and seventh days with a fall in pain score of 0 to 1 after the first day alone. The pain scores of all patients decreased to 1 by the first day except in one patient, and the scores decreased to 0 in all patients after 48 hours. Total analgesic intake ranged from 2 to 6 tablets (aceclofenac 100 mg per tablet) over the follow-up period of 7 days. Healing was satisfactory in all patients by the end of the seventh day. Conclusion: PRF showed early pain reduction in established dry socket with minimal analgesic intake. No patients had allergic reactions to PRF as it is derived from the patient's own blood. PRF showed good wound healing. Our study suggests that PRF should be considered as a treatment modality for established dry socket.
Keywords
Osteogenesis; Tooth extraction; Tooth impaction; Wound Healing; Pain reduction;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Sammartino G, Tia M, Marenzi G, di Lauro AE, D'Agostino E, Claudio PP. Use of autologous platelet-rich plasma (PRP) in periodontal defect treatment after extraction of impacted mandibular third molars. J Oral Maxillofac Surg 2005;63:766-70.   DOI
2 Simon D, Manuel S, Geetha V, Naik BR. Potential for osseous regeneration of platelet-rich plasma--a comparative study in mandibular third molar sockets. Indian J Dent Res 2004;15:133-6.
3 Mozzati M, Martinasso G, Pol R, Polastri C, Cristiano A, Muzio G, et al. The impact of plasma rich in growth factors on clinical and biological factors involved in healing processes after third molar extraction. J Biomed Mater Res A 2010;95:741-6.
4 Rutkowski JL, Johnson DA, Radio NM, Fennell JW. Platelet rich plasma to facilitate wound healing following tooth extraction. J Oral Implantol 2010;36:11-23.   DOI
5 Song JY, Kweon H, Kwon KJ, Park YW, Kim SG. The bone regenerative effect of silk fibroin mixed with platelet-rich fibrin (PRF) in the calvaria defect of rabbit. J Korean Assoc Oral Maxillofac Surg 2010;36:250-4.   DOI
6 Daly B, Sharif MO, Newton T, Jones K, Worthington HV. Local interventions for the management of alveolar osteitis (dry socket). Cochrane Database Syst Rev 2012;12:CD006968.
7 Fridrich KL, Olson RA. Alveolar osteitis following surgical removal of mandibular third molars. Anesth Prog 1990;37:32-41.
8 Blum IR. Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg 2002;31:309-17.   DOI
9 Vezeau PJ. Dental extraction wound management: medicating postextraction sockets. J Oral Maxillofac Surg 2000;58:531-7.   DOI
10 Caso A, Hung LK, Beirne OR. Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99:155-9.   DOI
11 Garcia AG, Grana PM, Sampedro FG, Diago MP, Rey JM. Does oral contraceptive use affect the incidence of complications after extraction of a mandibular third molar? Br Dent J 2003;194:453-5; discussion 445.   DOI
12 Muhonen A, Venta I, Ylipaavalniemi P. Factors predisposing to postoperative complications related to wisdom tooth surgery among university students. J Am Coll Health 1997;46:39-42.   DOI
13 Noroozi AR, Philbert RF. Modern concepts in understanding and management of the "dry socket" syndrome: comprehensive review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:30-5.   DOI
14 Bloomer CR. Straws do not cause dry sockets when third molars are extracted. Tex Dent J 2012;129:25-32.
15 Pal US, Singh BP, Verma V. Comparative evaluation of zinc oxide eugenol versus gelatin sponge soaked in plasma rich in growth factor in the treatment of dry socket: an initial study. Contemp Clin Dent 2013;4:37-41.   DOI
16 Reekie D, Downes P, Devlin CV, Nixon GM, Devlin H. The prevention of 'dry socket' with topical metronidazole in general dental practice. Br Dent J 2006;200:210-3; discussion 206; quiz 226.   DOI
17 Kaya GS, Yapici G, Savas Z, Gungormus M. Comparison of alvogyl, SaliCept patch, and low-level laser therapy in the management of alveolar osteitis. J Oral Maxillofac Surg 2011;69:1571-7.   DOI
18 Jovanovic G, Uric N, Krunic N, Tijanic M, Stojanovic S. Assessment of the effectiveness of low level laser in the treatment of alveolar osteitis. Vojnosanit Pregl 2011;68:506-10.   DOI
19 Haraji A, Lassemi E, Motamedi MH, Alavi M, Adibnejad S. Effect of plasma rich in growth factors on alveolar osteitis. Natl J Maxillofac Surg 2012;3:38-41.   DOI
20 Singh V, Pal US, Singh R, Soni N. Honey a sweet approach to alveolar osteitis: a study. Natl J Maxillofac Surg 2014;5:31-4.   DOI
21 Martinez-Zapata MJ, Marti-Carvajal A, Sola I, Bolibar I, Angel Exposito J, Rodriguez L, et al. Efficacy and safety of the use of autologous plasma rich in platelets for tissue regeneration: a systematic review. Transfusion 2009;49:44-56.   DOI
22 Anitua E, Orive G. Use of PRGF to accelerate bone and soft tissue regeneration in postextraction sites. Implant Dialogue 2003;36:3-14.
23 Aldecoa EA, Ortiz IA. A mew approach to bone regeneration: plasma rich in growth factors. Vitoria: Puesta al Dia Publicaciones; 2001:172.
24 Halberstein RA, Abrahmsohn GM. Clinical management and control of alveolalgia ("dry socket") with vitamin C. Am J Dent 2003;16:152-4.
25 Burgoyne CC, Giglio JA, Reese SE, Sima AP, Laskin DM. The efficacy of a topical anesthetic gel in the relief of pain associated with localized alveolar osteitis. J Oral Maxillofac Surg 2010;68:144-8.   DOI
26 Faizel S, Thomas S, Yuvaraj V, Prabhu S, Tripathi G. Comparision between neocone, alvogyl and zinc oxide eugenol packing for the treatment of dry socket: a double blind randomised control trial. J Maxillofac Oral Surg 2015;14:312-20.   DOI
27 Haghighat A, Bahri Najafi R, Bazvand M, Badrian H, Khalighinejad N, Goroohi H. The effectiveness of GECB pastille in reducing complications of dry socket syndrome. Int J Dent 2012;2012:587461.
28 Alexander RE. Dental extraction wound management: a case against medicating postextraction sockets. J Oral Maxillofac Surg 2000;58:538-51.   DOI
29 Plachokova AS, Nikolidakis D, Mulder J, Jansen JA, Creugers NH. Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review. Clin Oral Implants Res 2008;19:539-45.   DOI
30 Rani A, Mohanty S, Sharma P, Dabas J. Comparative evaluation of Er:Cr:YSGG, diode laser and alvogyl in the management of alveolar osteitis: a prospective randomized clinical study. J Maxillofac Oral Surg 2016;15:349-54.   DOI
31 Taberner-Vallverdu M, Nazir M, Sanchez-Garces MA, Gay-Escoda C. Efficacy of different methods used for dry socket management: a systematic review. Med Oral Patol Oral Cir Bucal 2015;20:e633-9.
32 Kolokythas A, Olech E, Miloro M. Alveolar osteitis: a comprehensive review of concepts and controversies. Int J Dent 2010;2010:249073.
33 Sharif MO, Dawoud BE, Tsichlaki A, Yates JM. Interventions for the prevention of dry socket: an evidence-based update. Br Dent J 2014;217:27-30.   DOI
34 Cardoso CL, Rodrigues MT, Ferreira Junior O, Garlet GP, de Carvalho PS. Clinical concepts of dry socket. J Oral Maxillofac Surg 2010;68:1922-32.   DOI
35 Torres-Lagares D, Serrera-Figallo MA, Romero-Ruiz MM, Infante-Cossio P, Garcia-Calderon M, Gutierrez-Perez JL. Update on dry socket: a review of the literature. Med Oral Patol Oral Cir Bucal 2005;10:81-5; 77-81.
36 Fazakerley M, Field EA. Dry socket: a painful post-extraction complication (a review). Dent Update 1991;18:31-4.