Browse > Article
http://dx.doi.org/10.5125/jkaoms.2012.38.1.2

Clinical application of auto-tooth bone graft material  

Park, Sung-Min (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University)
Um, In-Woong (Korea Tooth Bank)
Kim, Young-Kyun (Seoul National University Bundang Hospital)
Kim, Kyung-Wook (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.38, no.1, 2012 , pp. 2-8 More about this Journal
Abstract
Introduction: Auto-tooth bone graft material consists of 55% inorganic hydroxyapatite (HA) and 45% organic substances. Inorganic HA possesses properties of bone in terms of the combining and dissociating of calcium and phosphate. The organic substances include bone morphogenetic protein and proteins which have osteoinduction capacity, as well as the type I collagen identical to that found in alveolar bone. Auto-tooth bone graft material is useful as it supports excellent bone regeneration capacity and minimizes the possibility of foreign body reaction,genetic diseases and disease transmission. Materials and Methods: Implant placement combined with osteoinductive regeneration,preservation of extraction socket, maxillary sinus augmentation, and ridge augmentation using block type,powder type, and block+powder type autobone graft materialwere performed for 250 patients with alveolar bone defect and who visited the Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University from September 2009 to August 2011. Results: Clinical assessment: Among the 250 patients of auto-tooth bone graft, clinical assessment was performed for 133 cases of implant placement. The average initial stabilization of placed implants was 74 implant stability quotient (ISQ). Radiological assessment: The average loss of crestal bone in the mandible as measured 6 months on the average after the application of prosthesis load was 0.29 mm, ranging from 0 mm to 3.0 mm. Histological assessment: In the histological assessment, formation of new bone, densified lamellated bone, trabecular bones, osteoblast, and planting fixtures were investigated. Conclusion: Based on these results, we concluded that auto-tooth bone graft material should be researched further as a good bone graft material with osteoconduction and osteoinduction capacities to replace autogenous bone, which has many limitations.
Keywords
Auto-tooth bone; Osteoconduction; Osteoinduction;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kim YK, Kim SG, Byeon JH, Lee HJ, Um IU, Lim SC. Development of a novel bone grafting material using autogenous teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109:496-503.
2 Urist MR. Bone: formation by autoinduction. Science 1965;150: 893-9.
3 Murata M, Akazawa T, Takahata M, Ito M, Tazaki J, Hino J, et al. Bone induction of human tooth and bone crushed by newly developed automatic mill. J Ceram Soc Jpn 2010;118:434-7.
4 Kim YK, Yun PY, Kim SG, Lim SC. Sinus bone graft using combination of autogenous bone and BioOss(R): comparison of healing according to the ratio of autogenous bone. J Korean Assoc Oral Maxillofac Surg 2007;33:654-9.
5 Quattlebaum JB, Mellonig JT, Hensel NF. Antigenicity of freezedried cortical bone allograft in human periodontal osseous defects. J Periodontol 1988;59:394-7.
6 Schwartz Z, Mellonig JT, Carnes DL Jr, de la Fontaine J, Cochran DL, Dean DD, et al. Ability of commercial demineralized freezedried bone allograft to induce new bone formation. J Periodontol 1996;67:918-26.
7 Park SS, Kim SG, Lim SC, Ong JL. Osteogenic activity of the mixture of chitosan and particulate dentin. J Biomed Mater Res A 2008;87:618-23.
8 Gomes MF, dos Anjos MJ, Nogueira TO, Guimarães SA. Histologic evaluation of the osteoinductive property of autogenous demineralized dentin matrix on surgical bone defects in rabbit skulls using human amniotic membrane for guided bone regeneration. Int J Oral Maxillofac Implants 2001;16:563-71.
9 Catanzaro-Guimaraes SA, Catanzaro Guimaraes BP, Garcia RB, Alle N. Osteogenic potential of autogenic demineralized dentin implanted in bony defects in dogs. Int J Oral Maxillofac Surg 1986;15:160-9.
10 Gongloff RK. Vital root retention. Int J Oral Maxillofac Surg 1974; 3:97-9.
11 Fareed K, Khayat R, Salins P. Vital root retention: a clinical procedure. J Prosthet Dent 1989;62:430-4.
12 Sogal A, Tofe AJ. Risk assessment of bovine spongiform encephalopathy transmission through bone graft material derived from bovine bone used for dental applications. J Periodontol 1999;70:1053-63.
13 Han T, Carranza FA Jr, Kenney EB. Calcium phosphate ceramics in dentistry: a review of the literature. J West Soc Periodontol Periodontal Abstr 1984;32:88-108.
14 Kim SG, Kim HK, Lee SC. Combined implantation of particulate dentine, plaster of Paris, and a bone xenograft (Bio-Oss) for bone regeneration in rats. J Craniomaxillofac Surg 2001;29:282-8.
15 Ike M, Urist MR. Recycled dentin root matrix for a carrier of recombinant human bone morphogenetic protein. J Oral Implantol 1998;24:124-32.
16 Goncalves EAL. Study of the process of bone repair in surgical defects implanted with demineralized autogenous dentin matrix in radius of dog [thesis]. Bauru: University of Sao Paulo; 1997.
17 Gao J, Symons AL, Bartold PM. Expression of transforming growth factor-beta 1 (TGF-beta1) in the developing periodontium of rats. J Dent Res 1998;77:1708-16.
18 Saygin NE, Tokiyasu Y, Giannobile WV, Somerman MJ. Growth factors regulate expression of mineral associated genes in cementoblasts. J Periodontol 2000;71:1591-600.