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http://dx.doi.org/10.5125/jkaoms.2011.37.5.380

Bone regeneration of the fluoridated hydroxyapatite and the bio-glass in the rabbit cranium defect model  

Ahn, Hyo-Joon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dankook University)
Han, Se-Jin (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dankook University)
Kim, Kyung-Wook (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dankook University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.37, no.5, 2011 , pp. 380-385 More about this Journal
Abstract
Introduction: Hydroxyapatite ($Ca_{10}(PO_4)_6(OH)_2$, HA) is the main inorganic phase of human hard tissue that is used widely as the repair material for bones. When HA is applied to a bony defect, however, it can be encapsulated with fibrous tissue and float in the implanted area due to a lack of consolidation. Bioceramics as allogenic graft materials are added to HA to improve the rate and bone healing capacity. Fluoridated hydroxyapatite ($Ca_{10}(PO_4)_6(OH,F)_2$, FHA), where F- partially replaces the OH- in hydroxyapatite, is considered a good alternative material for bone repair owing to its solubility and biocompatibility. Materials and Methods: This study was designed to determine the bone healing capacity of FHA newly produced as a nanoscale fiber in the laboratory. HA and FHA with bioglass was implanted in a rabbit cranium defect and the specimen was analysed histologically. Results: 1. At 4 weeks, fibrous connective tissue and little bone formation was observed around the materials of the experimental group I implanted HA and bioglass. Newly formed bone was observed around the materials in the experimental group II implanted FHA and bioglass. 2. At 8 weeks, the amount of newly formed and matured bone was higher in experimental group II than in experimental group I and the control group. Conclusion: These results suggest that FHA and bioglass is a relatively favorable bone substitute with biocompatibility and better bone healing capacity than pure HA and bioglass.
Keywords
Durapatite; Fluor-hydroxylapatite; Bioglass; Bone Substitutes;
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