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http://dx.doi.org/10.5125/jkaoms.2010.36.1.16

The effect of hyaluronic acid on anti-inflammatory action in mouse  

Kim, Sang-Kyun (Hallym University)
Lee, Hyung-Seok (Hallym University)
Byeon, Kwang-Seob (Department of Oral and Maxillofacial Surgery, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University)
Lee, Young-Joo (Department of Oral and Maxillofacial Surgery, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University)
Hong, Soon-Min (Department of Oral and Maxillofacial Surgery, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University)
Choi, Mee-Ra (Department of Prosthodontics, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University)
Park, Jun-Woo (Department of Oral and Maxillofacial Surgery, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.36, no.1, 2010 , pp. 16-22 More about this Journal
Abstract
Purpose: The purpose of this study was not only to evaluate the relative mRNA expression of interleukin-$1{\beta}$(IL-$1{\beta}$), cyclooxygenase2 (COX-2) and prostaglandin E2 (PGE2) by RT-PCR analysis but to observe pattern of edema by light microscopic and electron microscope after topical apply of hyaluronic acid in inflammation-guided mouse. Material and methods: Mice of this study were devided into 4 groups: Control group (no inflammation guided), Positive control (inflammation guided + vaselin apply), Protopic group (inflammation guided + protopic apply), Hyaluronic group (inflammation guided + hyaluronic acid apply). Results: Hyaluronic group showed less expressions of IL-$1{\beta}$, COX-2, PGE2 than those of positive control & protopic group. Hyaluronic group revealed a decreased inflammation than positive control & protopic group in Light Microscope. Hyaluronic group appeared decreased edema of ear compare to positive control & protopic group in Elecron Microscope. Conclusion: It was considered that hyaluronic acid has an antiinflammatory effect for intercepting the gene expression of cytokines related to inflammation.
Keywords
Hyaluronic acid; Anti-inflammatory agent; Mice;
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