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LEIOMYOSARCOMA OF THE MAXILLARY SINUS : A CASE REPORT  

Choi, Se-Kyung (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Kim, Jae-Young (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Kim, So-Mi (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Kim, Hyun-Woo (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Nam, Jung-Woo (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Nam, Woong (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Cha, In-Ho (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Kim, Hyung-Jun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.35, no.6, 2009 , pp. 490-493 More about this Journal
Abstract
Leiomyosarcoma(LMS) is a malignant neoplasm of smooth muscle origin, which accounts for 7 % of all soft tissue sarcomas. The most common sites are the gastrointestinal tract and female genital tract. In contrast, primary LMS of the oral and maxillofacial area is rare due to the paucity of smooth muscle in this region. Especially, LMS of the paranasal sinuses is very rare and has an aggressive clinical behavior. Only 28 cases have been described in the english literature, and of these, only 3 patients treated with surgery had a disease-free survival. A 46-year-old woman came to our department for the evaluation of pain on right midface. After a diagnostic work-up, the lesion was diagnosed as LMS of the right maxillary sinus. The radical surgery was done and chemotherapy combined radiotherapy was followed from post operation 1 month. The patient was disease free at post-operation 1 year. We will report this case with literature review.
Keywords
Leimyosarcoma; Maxillary sinus; Paranasal sinus; Chemotherapy;
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1 Schenberg ME, Slootweg PJ, Koole R: Leiomyosarcomas of the oral cavity. Report of four cases and review of the literature. J Craniomaxillofac Surg 1993;21:342-347   DOI   ScienceOn
2 Fusconi M, Magliulo G, Della Rocca C, Marcotullio D, Suriano M, de Vincentiis M: Leiomyosarcoma of the sinonasal tract: a case report and literature review. Am J Otolaryngol 2002;23:108-111   DOI   ScienceOn
3 Barnes L. Pathology and genetics of head and neck tumours. Lyon, IARC Press,2005;39
4 Montgomery E, Goldblum JR, Fisher C: Leiomyosarcoma of the head and neck: a clinicopathological study. Histopathology 2002;40:518-525   DOI   ScienceOn
5 van Oosterom AT, Mouridsen HT, Nielsen OS, Dombernowsky P, Krzemieniecki K, Judson I, et al.: Results of randomised studies of the EORTC Soft Tissue and Bone Sarcoma Group (STBSG) with two different ifosfamide regimens in first- and secondline chemotherapy in advanced soft tissue sarcoma patients. Eur J Cancer 2002;38:2397-2406   DOI   ScienceOn
6 Maki RG, Wathen JK, Patel SR, Priebat DA, Okuno SH, Samuels B, et al.: Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002 [corrected]. J Clin Oncol 2007;25:2755-2763   DOI   ScienceOn
7 Worden FP, Taylor JM, Biermann JS, Sondak VK, Leu KM, Chugh R, et al.: Randomized phase II evaluation of 6 g/m2 of ifosfamide plus doxorubicin and granulocyte colony-stimulating factor (G-CSF) compared with 12 g/m2 of ifosfamide plus doxorubicin and G-CSF in the treatment of poor-prognosis soft tissue sarcoma. J Clin Oncol 2005;23:105-112   DOI   ScienceOn
8 Pinheiro Jde J, Alves Sde M, Jr., Okuda E, Jorge WA, Jaeger RG, de Araujo NS: Primary leiomyosarcoma of the mandible. A case report. Med Oral Patol Oral Cir Bucal 2007;12:E56-59
9 Farman AG, Kay S: Oral leiomyosarcoma. Report of a case and review of the literature pertaining to smooth-muscle tumors of the oral cavity. Oral Surg Oral Med Oral Pathol 1977;43:402-409   DOI   ScienceOn
10 Izumi K, Maeda T, Cheng J, Saku T: Primary leiomyosarcoma of the maxilla with regional lymph node metastasis. Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;80:310-319   DOI   ScienceOn
11 Miettinen M, Lehto VP, Ekblom P, Tasanen A, Virtanen I: Leiomyosarcoma of the mandible: diagnosis as aided by immunohistochemical demonstration of desmin and laminin. J Oral Pathol 1984;13:373-381   DOI   PUBMED
12 Neville BW. Oral and maxillofacial pathology 3rd ed. ed. Edinburgh, Saunders,2009;559
13 Vilos GA, Rapidis AD, Lagogiannis GD, Apostolidis C: Leiomyosarcomas of the oral tissues: clinicopathologic analysis of 50 cases. J Oral Maxillofac Surg 2005;63:1461-1477   DOI   ScienceOn
14 Issels RD, Schlemmer M: Current trials and new aspects in soft tissue sarcoma of adults. Cancer Chemother Pharmacol 2002;49 Suppl 1:S4-8   DOI
15 Ethunandan M, Stokes C, Higgins B, Spedding A, Way C, Brennan P: Primary oral leiomyosarcoma: a clinico-pathologic study and analysis of prognostic factors. Int J Oral Maxillofac Surg 2007;36:409-416   DOI   ScienceOn
16 Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, et al.: Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003;349:2091-2098   DOI   ScienceOn
17 Prasad KC, Alva TB, Khadilkar U, Madhu D: Leiomyosarcoma of the maxillary sinuses: report of two cases. Ear Nose Throat J 2004;83:122, 124, 126-127
18 Santoro A, Tursz T, Mouridsen H, Verweij J, Steward W, Somers R, et al.: Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J Clin Oncol 1995;13:1537-1545   DOI
19 Yadav R, Bharathan S: Leiomyosarcoma of the buccal mucosa: a case report with immunohistochemistry findings. J Oral Sci 2008;50:215-218   DOI   ScienceOn