Browse > Article

APPLICATION OF 0.2% HYALURONIC ACID GEL IN ORAL SURGICAL WOUND : A RANDOMIZED DOUBLE-BLIND STUDY  

Kim, Jae-Yoon (School of Dentistry, Graduate School, Seoul National University)
Lee, Jin-Yong (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University)
Bae, Kwang-Hak (Department of Preventive and Public Health Dentistry, School of Dentistry, Seoul National University)
Lee, Jong-Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.34, no.2, 2008 , pp. 157-165 More about this Journal
Abstract
The aim of this study was to evaluate the efficacy of a topical 0.2% hyaluronic acid (HA) preparation in the management of wound after removal of arch bar for facial bone fracture and a suture site after orthognatic, oral cancer or oral surgery. Forty patients participated in a randomized, placebo controlled, double-blind trial to evaluate the efficacy of the topical HA and preparation. HA topically applied to the wound after removal of arch bar or stitch out, 3 times a day for 4 weeks. Evaluation is performed once a week for 4 weeks. For subjective evaluation, relative pain reduction in visual analog scale (VAS) and existence of heat sensation was accessed. For objective evaluation, gross evaluation, papilla index, existence of wound dehiscence, redness and swelling was checked. The same evaluation was performed in each arch bar group and suture group. For whole subject, 0.2% HA group resulted higher reduction than placebo group in pain of site in first week with significancy. Same findings were seen other weeks but there was no significancy. 0.2% HA group had better result than placebo in objective evaluation (papilla index, wound dehiscence, redness and swelling), but in gross evaluation placebo had better result than 0.2% HA group with no significancy. Subject was divided into suture group and arch bar group. Same aspect was seen, but only suture group had significancy not arch bar group in pain reduction score. 0.2% HA group resulted higher reduction than placebo group in pain of site in first week with significancy, especially in suture group. It reveals topical application of HA in wound especially suture site reduced pain in early stage. And 0.2% HA group had better result than placebo in papilla index, redness and swelling with no statistical significancy. In conclusion, HA has effect of pain reduction and healing promotion in the mucosal wound after oral surgery.
Keywords
Hyaluronic acid; Double blind test; Wound healing; Oral Surgery;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Suresh PR, Allison C, Damian A, Peter-john W: The effect of a hyaluronic acid-based nasal pack on mucosal healing in a sheep model of sinusitis. Oceanside Public 2005;19:572-576
2 Bartold M, Weibkin OW, Thonard JC: Glycosaminoglycans of human gingival epithelium and connective tissue. Connective Tissue Research 1981;258;919-922
3 Ghosh K, Ren XD, Shu XZ, Prestwich GD, Clark RA: Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing. Tissue Engineering 2006;12:601-613   DOI   ScienceOn
4 Yasushi F, Koichi U, Hiromichi F, Kentaro K, Yoshimitsu K: Skin regenerationfor children with burn sacr contrature using autologous cultured dermal substitutes and superthin auto-skin grafts. Ann Plast Surg 2006;57:408-414   DOI   ScienceOn
5 Alexander P, Monika M, Brita W, Philip R: The clinical application of hyaluronic acid in gingivitis therapy. Quintessence Int 2005;36:531-538
6 Jentsch H, Pomowshi R, Kundt G, Gocke R: Treatment of gingivitis with hyaluronan. J Clin Periodontol 2003;30:159-164   DOI   ScienceOn
7 Eiji T, Tatsunori I, Diego A, Nobuhiko K, Theo VE, Masao T, et al: The effect of experimental cartilage damage and impairment and restoration of synovial lubrication on friction on the temporomandibular joint. J Orofac Pain 2005;19:331-336
8 Eiji T, Tatsunori I, Eizo Y, Masao T, Takashi T: The effect of removal of the disc on te friction in the temporomandibular joint. J Oral Maxillofac Surg 2006;64:1221-1224   DOI   ScienceOn
9 Chung-Lak K: Statistics for clinical trial and analysis. Biowave 2004;6(21)
10 Sattar A, Rooney P, Kumar S: Application of angiogenic oligosaccharides of hyaluronan increases blood vessel numbers in rat skun. J Invest Dermatol 1994;103:576-579   DOI   ScienceOn
11 West DC, Hampson IN, Arnold F: Angiogenesis induced by degradation products of hyaluronic acid. Science 1991;228:1324-1326
12 Wang TW, Sun JS, Wu HC, Tsuang YH, Wang WH, Lin FH: The effect of gelatin-chondroitin sulfate-hyaluronic acid skin substitute on wound healing in SCID mice. Biomaterials 2006;27:5689-5697   DOI   ScienceOn
13 Hita-Iglesias P, Torres-Lagares D, Gutierrez-Perez JL: Evaluation of the clinical behaviour of a polyvinylpyrrolidone and sodium hyalonurate gel in patients subjected to surgical treatment with $CO_{2}$ laser. Int J Oral Maxillofac Surg 2006;35:514-517   DOI   ScienceOn
14 Veronique V, Psdvsl V, Jrtome K: Efficacy and safety of hyaluronic acid in the management of acute wounds. Am J Clin Dermatol 2006;7:353-357   DOI   ScienceOn
15 Cardaropoli D, Re S, Corrente G: The Papilla Presence Index (PPI) : a new system to assess interproximal papillary levels. Int J Periodontics Restorative Dent 2004;24:488-92   DOI
16 Xu Y, Hofling K, Fimmers R, Frentzen M, Jervoe-Storm PM: Clinical and microbiological effects of topical subgingival application of hyaluronic acid gel adjunctive to scaling and root planing in the treatment of chronic periodontitis. J Periodontol 2004;75:1114-1118   DOI   ScienceOn
17 Kaustabh G, Xiang-Dong R, Xiao Zheng S, Glenn DP, Richard AFC: Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing. Tissue Engineering 2006;12:601-613   DOI   ScienceOn
18 Ricard DP, Simon M, Irene ML, Harshad AN: The rold of hyaluronic acid wound healing ; Assessment of clinical evidence. Am J Clin Dermatol 2005;6:393-402   DOI   ScienceOn
19 Richard DP, Victoria DG, Irene ML, Harshad AN: A comparison of tissue-engineered hyaluronic acid dermal matrices in a human wound model. Tissue Engineering 2006;12:3001-3011
20 Kayhan O, Huseyin Y, Mustafa CA, Hamdi A, Bahar K, Yavuz U: Effectiveness of merogel hyaluronic acid on tympanic membrane perforations. Acta Oto-Laryngologica 2006;126:1158-1163   DOI   ScienceOn
21 Cabrera RC, Siebert JW, Eidelman Y, Gold LI, Longaker MT, Garg HG: The in vivo effect of hyaluronan associated proteincollagen complex in wound repair. Biochem Mol Biol Int 1995;37:151-158
22 Toole BP: Hyaluronan and its binding proteins, the hyaladherins. Current Opinion in Cell Biology 1990;2:839-844   DOI   ScienceOn
23 Heldin O, Laurent TC, Heldin CH: Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts. Biochem J 1989;258:919-922   DOI
24 Tammi r, Tammi M, Hakkinen L, Larjave H: Histochemical localization of hyaluronate in human oral epithelium using a specific hyaluronate-binding probe. Arch oral Biol 1990;35:219-224   DOI   ScienceOn
25 Weigel PH, Frost SJ, LeBoeuf RD, McGary CT: The specific interaction between fibrin (ogen) and hyaluronan: possible consequences in haemostasis, inflammation and wound healing. Chichester; Wiley, 1989;19:2101-2127
26 Vag J, Fazekas A: Influence of restorative manipulations on the blood perfusion of human marginal gingiva as measured by laser doppler flowmetry. J Oral Rehabil 2002;29:52-57   DOI   ScienceOn
27 Charles NB, Thomas G, Glenn TC, Jill R, Vivek S, Changruri L et al: Use of sodium hyaluronate in treating temporomandibular joint disorders. J Oral Maxillofac Surg 1993;51:232-242   DOI   ScienceOn
28 Nolan A, Baillie C, Badminton K, Rudralinghan M, Seymour RA: The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration. J Oral Pathol Med 2006;35:461-465   DOI   ScienceOn
29 Mark AS, Walter TA, Al-Karim FR, Alan LR, George JE: Sustained relief of oral aphthous ulcer pain from topical diclofenac in hyaluronan. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;84:356-361   DOI   ScienceOn