Browse > Article

Effects of fibrin glue on bone formation in combination with deproteinized bone xenografts in humans  

Kim, Moon-Su (Department of Oral & Maxillofacial Surgery, College of Dentistry, Chosun University)
Kim, Su-Gwan (Department of Oral & Maxillofacial Surgery, College of Dentistry, Chosun University)
Lim, Sung-Chul (Department of Pathology, College of Medicine, Chosun University)
Kim, Hak-Kyun (Department of Oral & Maxillofacial Surgery, College of Dentistry, Chosun University)
Moon, Seong-Young (Department of Oral & Maxillofacial Surgery, College of Dentistry, Chosun University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.34, no.1, 2008 , pp. 19-27 More about this Journal
Abstract
Thirty-six sinus grafts were performed in 34 patients with an alveolar crest bone height in the posterior maxilla of 3 to 5 mm before grafting. The sinuses were grafted using Bio-Oss alone or mixed with fibrin glue. Group 1 was the control group and included 25 patients who received a xenograft mixed in saline. Group 2 comprised 9 patients who received a xenograft and fibrin glue. The study was further subdivided at the time of 9 months. This histologic study evaluated by hematoxylin-eosin (H&E) and histomorphometric analysis whether fibrin glue in combination with Bio-Oss enhances bone regeneration in sinus floor elevation in humans. The new bone formation was better in Group 2 than in Group 1, but the difference was not significant. The absorption of the graft material was faster in Group 2 than in Group 1, in the short term, but better in Group 1 over the long term, although the difference was not significant. Lamellar bone was formed earlier in Group 1 compared to Group 2, but the difference was not significant. Overall, the surgery site stabilized earlier with new bone formation in Group 2 than in Group 1, but the difference was not significant. Combining a fibrin sealant and Bio-Oss could lead to improved scaffolds for bone tissue engineering based on the synergistic effects of the biomaterials. Therefore, Bio-Oss or Bio-Oss plus Tisseel may be used depending on the situation.
Keywords
Fibrin glue; Bone formation; Deproteinized bone xenografts;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Valentini P, Abensur D, Densari D, Graziani JN, Hammerle C: Histological evaluation of Bio-Oss in a 2-stage sinus floor elevation and implantation procedure. A human case report. Clin Oral Implants Res 1998;9:59-64   DOI   ScienceOn
2 Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR: Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:638-646   DOI   ScienceOn
3 Stefani CM, Machado MA, Sallum EA, Sallum AW, Toledo S, Nociti FH Jr: Platelet-derived growth factor/insulin-like growth factor-1 combination and bone regeneration around implants placed into extraction sockets: a histometric study in dogs. Implant Dent 2000;9:126-131   DOI
4 Matras H: Fibrin seal: the state of the art. J Oral Maxillofac Surg 1985;43:605-611   DOI   ScienceOn
5 Diamond MP, Kruger M, Saed GM: Effect of Tisseel on expression of tissue plasminogen activator and plasminogen activator inhibitor-1. Fertil Steril 2004;81:1657-1664   DOI   ScienceOn
6 von Arx T, Cochran DL, Hermann JS, Schenk RK, Buser D: Lateral ridge augmentation using different bone fillers and barrier membrane application. A histologic and histomorphometric pilot study in the canine mandible. Clin Oral Implants Res 2001;12:260-269   DOI
7 Jeong TY, Kim SG: Histologic study of sinus grafting with Bio-Oss for implant placement. Hosp Dent (Tokyo) 2005;17:87-92
8 Tayapongsak P, O'Brien DA, Monteiro CB, Arceo-Diaz LY: Autologous fibrin adhesive in mandibular reconstruction with particulate cancellous bone and marrow. J Oral Maxillofac Surg 1994;52:161-165   DOI   ScienceOn
9 Nakamura K, Koshino T, Saito T: Osteogenic response of the rabbit femur to a hydroxyapatite thermal decomposition product-fibrin glue mixture. Biomaterials 1998;19:1901-1907   DOI   ScienceOn
10 Kim MJ, Kim YK, Kim SG: Various bone grafting materials in the dental surgery, Narae Publishing Inc,, 2004
11 Hising P, Bolin A, Branting C: Reconstruction of severely resorbed alveolar ridge crests with dental implants using a bovine bone mineral for augmentation. Int J Oral Maxillofac Implants 2001;16:90-97
12 Cordaro L: Bilateral simultaneous augmentation of the maxillary sinus floor with particulated mandible. Report of a technique and preliminary results. Clin Oral Implants Res 2003;14:201-206   DOI   ScienceOn
13 Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM: Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:299-303   DOI   ScienceOn
14 Warrer K, Karring T: Effect of Tisseel on healing after periodontal flap surgery. J Clin Periodontol 1992;19:449-454   DOI
15 Piattelli M, Favero GA, Scarano A, Orsini G, Piattelli A: Bone reactions to anorganic bovine bone (Bio-Oss) used in sinus augmentation procedures: a histologic long-term report of 20 cases in humans. Int J Oral Maxillofac Implants 1999;14:835-840
16 Bosch P, Lintner F, Arbes H, Brand G: Experimental investigations of the effect of the fibrin adhesive on the Kiel heterologous bone graft. Arch Orthop Trauma Surg 1980;96:177-185   DOI
17 Yamada Y, Boo JS, Ozawa R, Nagasaka T, Okazaki Y, Hata K, Ueda M: Bone regeneration following injection of mesenchymal stem cells and fibrin glue with a biodegradable scaffold. J Craniomaxillofac Surg 2003;31:27-33   DOI   ScienceOn
18 Marktl W, Rudas B: The effect of factor XIII on wound granulation in the rat. Thromb Diath Haemorrh 1974;32:578-581
19 Kawamura M, Urist MR: Human fibrin is a physiologic delivery system for bone morphogenetic protein. Clin Orthop Relat Res 1988;235:302-310
20 Wittkampf AR: Fibrin glue as cement for HA-granules. J Craniomaxillofac Surg 1989;17:179-181   DOI
21 Valentini P, Abensur D: Maxillary sinus floor elevation for implant placement with demineralized freeze-dried bone and bovine bone (Bio-Oss): a clinical study of 20 patients. Int J Periodontics Restorative Dent 1997;17:232-241
22 Pinholt EM, Bang G, Haanaes HR: Alveolar ridge augmentation in rats by Bio-Oss. Scand J Dent Res 1991;99:154-161
23 Keller J, Andreassen TT, Joyce F, Knudsen VE, Jorgensen PH, Lucht U: Fixation of osteochondral fractures. Fibrin sealant tested in dogs. Acta Orthop Scand 1985;56:323-326   DOI   ScienceOn
24 Thorn JJ, Sorensen H, Weis-Fogh U, Andersen M: Autologous fibrin glue with growth factors in reconstructive maxillofacial surgery. Int J Oral Maxillofac Surg 2004;33:95-100   DOI   ScienceOn
25 Boyne PJ, James RA: Grafting of the maxillary sinus floor with autogenous marrow and bone. J Oral Surg 1980;38:613-616
26 Ohazama A, Isatsu K, Hatayama J, Okamatsu Y, Tachikawa T, Hasegawa K: Periodontal tissue regeneration using fibrin tissue adhesive material in vitro and in vivo. Periodontal Clin Investig 1996;18:26-38
27 Sanchez AR, Sheridan PJ, Eckert SE, Weaver AL: Influence of platelet-rich plasma added to xenogeneic bone grafts in periimplant defects: a vital fluorescence study in dogs. Clin Implant Dent Relat Res 2005;7:61-69   DOI   ScienceOn
28 Hurzeler MB, Kirsch A, Ackermann KL, Quinones CR: Reconstruction of the severely resorbed maxilla with dental implants in the augmented maxillary sinus: a 5-year clinical investigation. Int J Oral Maxillofac Implants 1996;11:466-475
29 Jensen SS, Aaboe M, Pinholt EM, Hjorting-Hansen E, Melsen F, Ruyter IE: Tissue reaction and material characteristics of four bone substitutes. Int J Oral Maxillofac Implants 1996;11:55-66
30 Niedhart C, Maus U, Redmann E, Schmidt-Rohlfing B, Niethard FU, Siebert CH: Stimulation of bone formation with an in situ setting tricalcium phosphate/rhBMP-2 composite in rats. J Biomed Mater Res 2003;65:17-23