Browse > Article

HISTOLOGICAL AND CLINICAL STUDY OF ARTIFICIAL DERMIS IMPLANTATION FOR RESTORATION OF SOFT TISSUE DEFECTS  

Ryu, Sun-Youl (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University)
Kim, Sun-Kook (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.32, no.5, 2006 , pp. 410-417 More about this Journal
Abstract
The present study was aimed to compare the resorption rate and the histological change of the autogenous dermis and the artificial dermis (Terudermis$^{(R)}$) after the transplantation, and to report the clinical results of the use of Terudermis$^{(R)}$ in order to restore the soft tissue defect. Twenty mature rabbits, weighing about 2 kg, were used for the experimental study. The autogenous dermis and the Terudermis$^{(R)}$ size 1${\times}$1 cm were transplanted to the space between the external abdominal oblique muscle and the external abdominal oblique fascia of the each rabbits. They were divided into 4 groups (n=5 each) and gathered at 1, 2, 4, and 8 weeks after the transplantation. The resorption rate was calculated, and H-E stain was preformed to observe the histological changes. The chart review of the 17 patients who received Terudermis$^{(R)}$ graft to the facial soft tissue defects was conducted for the clinical study. The resorption rate at 8 weeks after the transplantation was 21.5% for the autogenous dermis, and 36.4% Terudermis$^{(R)}$. In microscopic examinations, the infiltration of the inflammatory cells and the epidermal inclusion cyst were observed in the autogenous dermis graft. The neovascularization and the progressive growth of the new fibroblast were shown in the Terudermis$^{(R)}$ graft. In clinical data of 17 patients, the size of the grafted Terudermis$^{(R)}$ was from 1.5$cm^2$ to 7.5$cm^2$ (average 3.5$cm^2$). Follow-up ranged from 5 to 25 months. Fourteen patients with cleft palate demonstrated stability of the graft and unremarkable complications. But unstability of the graft and the partial relapse were observed in three patients received the vestibuloplasty. These results indicate that Terudermis$^{(R)}$ can be available substitute of autogenous dermis because of the stability about resorption, the histocompatibility, and the unremarkable clinical complications.
Keywords
Autogenous dermis; Artificial dermis (Terudermis$^{(R)}$); Resorption rate; Histological change; Clinical result;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Ersek RA: Transplantation of purified autologous fat: a 3-year follow-up is disappointing. Plast Reconstr Surg 1991;87:219-227   DOI   ScienceOn
2 Matsui R, Okura N, Osaki K, Konishi J: Histological evaluation of skin reconstruction using artificial dermis. Biomaterials 1996;17:995-1000   DOI   ScienceOn
3 Hatoko M, Kuwahara M, Tanaka A: Application of artificial dermis graft to correct a depression after tissue resection. Ann Plast Surg 2000;45:633-640   DOI
4 David K, Nosan BS, James W: Preservation of facial contour during parotidectomy. Otolaryngol Head Neck Surg 1991;104:293-298   DOI
5 Sawhney CP, Banerjee TN, Chakravarti RN: Behaviour of dermal fat transplants. Br J Plast Surg 1969;22:169-176   DOI   ScienceOn
6 Kremenak CR, Huffman WC, Olin W JR: Growth of maxillae in dogs after palatal surgery. Cleft Palate J 1967;4:6-17
7 Jonsson G, Stenstrom S: Maxillary growth after palatal surgery: An experimental study on dogs. Scand J Plast Reconstr Surg 1978; 12:131-137   DOI
8 Jonsson G, Hallmans G: Healing of palatal defects with and without skin graft: An intraindividual experimental study on dogs. Int J Oral Surg 1980;9:128-139   DOI
9 Graber TM: Craniofacial morphology in cleft palate and cleft lip deformities. Surg Gynecol Obstet 1949;88:359
10 Yurugi S, Hatoko M, Kuwahara M, Tanaka A: Usefulness and limitations of artificial dermis implantation for posttraumatic deformity. Aesth Plast Surg 2002;26:360-364   DOI
11 Wolf DL: Complication following lip augmentation with Gore-Tex. Plast Reconstr Surg 1995;95:1334-1341
12 Herbert O: Fundamental investigations into the problems related to cleft palate surgery. Br J Plast Surg 1958;11:97   DOI
13 Conley JJ, Clairmont AA: Dermal fat fascia grafts. Otolaryngol 1978;86:641-649   DOI
14 Jones FR, Schwartz BM, Silverstein P: Use of nonimmunogenic acellular dermal allograft for soft tissue augmentation: A preliminary report. Aesth Surg 1996;16:196-202   DOI
15 Owsley TG, Taylor CO: The use of Gore-Tex for nasal augmentation: a retrospective analysis of 106 patients. Plast Reconstr Surg 1994; 94:241-250   DOI   ScienceOn
16 Howard A, Nester D: Lip Augmentation using an alloderm graft. J Oral Maxillofac Surg 1998;56:722-727   DOI   ScienceOn