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THE EXPRESSION OF FGF-5 AND FGF-7 IN THE CYCLOSPORIN A-INDUCED GINGIVAL HYPERPLASIA  

Jeong, Mi-Hyang (Dept. of Orthodontics, College of Dentistry, Seoul National University)
Kim, Seong-Gon (Dept. of Oral and Maxillofacial Surgery, College of Medicine, Hallym University)
Yun, Kyoung-In (Dept. of Oral and Maxillofacial Surgery, College of Medicine, Eulji University)
Nahm, Dong-Seok (Dept. of Orthodontics, College of Dentistry, Seoul National University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.32, no.3, 2006 , pp. 216-221 More about this Journal
Abstract
Cyclosporin A-induced gingival hyperplasia is frequently found in the patients who have been received an immunosuppressant for the organ transplantation. However, its exact mechanism is still unknown. The expression of FGF-5 and FGF-7 were studied in cyclosporine A-induced gingival hyperplasia (CGH) and inflammatory gingival hyperplasia (IGH). Immunohistochemistry and in situ hybridization were used for localization of protein and mRNA. The expression of FGF-5 and FGF-7 was different from CGH and IGH. FGF-5 and FGF-7 was strongly expressed in fibroblast in CGH (P<0.005 and P<0.05, respectively). FGF-5 mRNA was localized in the middle portion of connective tissue. FGF-7 mRNA was also identified in fibroblasts and mast cells. In conclusion, FGF-5 and FGF-7 were produced excessively by fibroblasts in CGH. Considering their known functions, their expression in CGH is important for production of collagen and proliferation of fibroblasts.
Keywords
Cyclosporin-A; Gingival hyperplasia; FGF-5; FGF-7;
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