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EXPRESSION OF OSTEONECTIN ON DISTRACTION OSTEOGENESIS IN THE RABBIT MANDIBLE  

Kim, Dong-Joon (Department of Oral & Maxillofacial Surgery, Graduate School of Clinical Dental Science, The Catholic University of Korea)
Jee, Yu-Jin (Division of Oral & Maxillofacial Surgery, Department of Dentistry, St. Vincent's Hosptital, The Catholic University of Korea)
Song, Hyun-Chul (Division of Oral & Maxillofacial Surgery, Department of Dentistry, St. Vincent's Hosptital, The Catholic University of Korea)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.30, no.5, 2004 , pp. 391-399 More about this Journal
Abstract
Distraction osteogenesis has been thought to be promising technique for replacing bone graft in maxilla and mandible. The purpose of this study was to investigate the expression of osteonectin on distraction osteogenesis. Sixteen rabbits were used for this experiment. Osteotomy was performed between premolar and mental foramen. On the experimental group, distraction device was connected to the respective bone segments. On the control group, bone segments were fixed using plate and screws after osteotomy. Distraction was carried out at the rate of 0.7mm per day to obtain a 4.9mm elongation on the experimental group. After 3 days, 7 days, 14 days, and 28 days two rabbits of each group were sacrificed. The results obtained from this study were as follow : Experimental group was observed that the gaps between the distracted bone edges were occupied by new bone. Expression of Osteonectin were detected throughout the experiment in both groups and Expression of Osteonectin were markedly increased during distraction and consolidation period in experimental group than control group. From these results, it could be stated that distraction was shown to improve and accelerate bone formation and mechanical stress like distraction has considerable effects on osteonectin.
Keywords
Distraction osteogenesis; Osteonectin; Histological analysis; RT-PCR analysis;
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1 Snyder CC, Levine GA, Swanson HM, Browne EZ Jr: Mandibular lengthening by gradual distraction. Preliminary report. Plast Reconstr Surg 1973;51:506-508   DOI   PUBMED   ScienceOn
2 Yasui N, Sato M, Ochi T: Three modes of ossification during distraction osteogenesis in the rat. J Bone Joint Surg Br 1997;79:824-830   DOI   PUBMED
3 Stewart KJ, Lvoff GO, White SA, Bonar SF, Walsh WR, Smart RC, et al: Mandibular distraction osteogenesis: A comparison of distraction rates in the rabbit model. J Craniomaxillofac Surg 1998;26:43-49   DOI   PUBMED   ScienceOn
4 Mehrara BJ, Rowe NM, Steinbrech DS, Dudziak ME, Saadeh PB, McCarthy JG et al: Rat mandibular distraction osteogenesis: II. Molecular analysis of transforming growth factor beta-1 and osteocalcin gene expression. Plast Reconstr Surg 1999;103:536-547   DOI   ScienceOn
5 백선호, 안병근, 박영주, 박희건, 박준우, 이건주 등: 성견 하악골 절단 후 기계적 골 견인에 의해 형성된 골 신장부에 대한 시기별 조직학적 변화. 대구외지 2001;27:404-413   과학기술학회마을
6 White SH, Kenwright J: The timing of distraction of an osteotomy. J Bone Joint Surg Br 1990;72:356-361   PUBMED
7 Morone MA, Boden SD, Hair G: Gene expression during autograft lumbar spine fusion and the effect of Bone Morphogenetic Protein 2. Clin Orthop 1998;351:252-265
8 심종섭, 최인호, 성상철: 백서 경골에서 신연골 형성시 신연속도가 골아세포계의 활성도에 미치는 영향. 대한정형외과학회지 1996;31:790-800
9 Tavakoli K, Walsh WR, Bonar F, Smart R, Wulf S, Poole MD: The role of latency in mandibular osteodistraction. J Craniomaxillofac Surg 1998;26:209-219   DOI   PUBMED   ScienceOn
10 Aronson J, Shen XC, Skinner RA, Hogue WR, Badger TM, Lumpkin CK Jr: Rat model of distraction osteogenesis. J Orthop Res 1997;15:221-226   DOI   ScienceOn
11 McCarthy JG, Schreiber J, Karp N, Thorne CH, Grayson BH: Lengthening the human mandible by gradual distraction. Plast Reconstr Surg 1992;89:1-8   DOI   ScienceOn
12 Ilizarov GA: The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. Clin Orthop 1989;239:263-285
13 Rowe NM, Mehrara BJ, Dudziak ME, Steinbreck DS, Mackool RJ, Gittes GK, et al: Rat mandibular distraction osteogenesis: Part I. Histologic and radiographic analysis. Plast Reconstr Surg 1998;102:2022-2032   DOI   ScienceOn
14 Meyer U, Meyer T, Vosshans J, Joos U: Decreased expression of osteocalcin and osteonectin in relation to high strains and decreased mineralization in mandibular distraction osteogenesis. J Craniomaxillofac Surg 1999;27:222-227   DOI   PUBMED   ScienceOn
15 Yasui N, Kojimoto H, Sasaki K, Kitada A, Shimizu H, Shinomura Y: Factors affecting callus distraction in limb lengthening. Clin Orthop 1993;293:55-60
16 Codivilla A: On the means of lengthening in the lower limb, the muscles and tissues which are shortened through deformity. Am J Orthop Surg 1905;2:353-369
17 Ilizarov GA: The tension-stress effect on the genesis and growth of tissues: Part I. The influence of stability of fixation and soft-tissue preservation. Clin Orthop 1989;238:249-281
18 Nakase T, Sugimoto M, Sato M: Switch of osteonectin and osteopontin mRNA expression in the process of cartilage-to-bone transition during fracture repair. Acta Histiochem 1998;100:287-295   DOI   ScienceOn
19 김부경, 신상훈, 김종렬: 백서경골에서 신연속도에 따른 골형성 비교 연구. 대구외지 2000;26:620-627
20 Li G, Simpson AH, Kenwright J, Triffitt JT: Assessment of cell proliferation in regenerating bone during distraction osteogenesis at different distraction rates. J Orthop Res 1997;15:765-772   DOI   ScienceOn
21 Minematsu K, Tsuchiya H, Taki J, Tomita K: Blood flow measurement during distraction osteogenesis. Clin Orthop 1998;347:229-235
22 Delloye C, Delefortrie G, Coutelier L, Vincent A: Bone regenrate formation in cortical bone during distraction lengthening. An experimental study. Clin Orthop 1990;250:34-42
23 Sawaki Y, Hagino H, Yamamoto H, Ueda M: Trifocal distraction osteogenesis for segmental mandibular defect: a technical innovation. J Craniomaxillofac Surg 1997;25:310-315   DOI   PUBMED   ScienceOn
24 White SH, Kenwright J: The importance of delay in distraction of osteotomies. Orthop Clin North Am 1991;22:569-579   PUBMED
25 임순모, 안병근, 박영주, 박희건, 박준우, 이건주 등: 성견 하악 골체부 신장시 신장부위의 증식세포핵항원과 제 1형 교원질 발현에 관한 연구. 대구외지 2001;27:386-393   과학기술학회마을