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MALIGNANT PERIPHERAL NERVE SHEATH TUMOR ON PALATE: A CASE REPORT  

Kwon, Min-Su (Department of Oral & Maxillofacial Surgery, School of Dentistry, Institute of Oral Bio-Science, Chonbuk National University)
Lee, Hyun-Sang (Department of Oral & Maxillofacial Surgery, School of Dentistry, Institute of Oral Bio-Science, Chonbuk National University)
Kim, Hyun-Chang (Department of Oral & Maxillofacial Surgery, School of Dentistry, Institute of Oral Bio-Science, Chonbuk National University)
Ko, Seung-O (Department of Oral & Maxillofacial Surgery, School of Dentistry, Institute of Oral Bio-Science, Chonbuk National University)
Shin, Hyo-Keun (Department of Oral & Maxillofacial Surgery, School of Dentistry, Institute of Oral Bio-Science, Chonbuk National University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.30, no.3, 2004 , pp. 228-233 More about this Journal
Abstract
Summary: The malignant peripheral nerve sheath tumor(MPNST) is an aggressive neoplasm and can either arise independently or result from malignant change in preexisting neurofibromatosis (von Recklinghausen's disease). Its histologic characteristics remain controversial, but currently it is believed that the schwann cell is the origin of the peripheral nerve sheath tumors. MPNST is an uncommon neoplasm of the head and neck region, and its presentation in the oral cavity is quite rare. In this study, we report a patient with a rare case of a MPNST involving the maxilla. A case report: A 29-year-old female presented with a chief complaint of painless swelling with bleeding tendency on the left maxillary tuberosity area 2 months ago. Clinical examination showed a $5.0{\times}3.0cm^2$ sized, indurative swelling on the site. Conventional radiographs showed a relatively well-defined soft tissue mass involving the left maxillary sinus, and destruction of the anterior, posterolateral walls of the left maxillary sinus. Subtotal maxillectomy and split-thickness skin graft from thigh were undertaken. In histochemical and immunohistochemical studies, the specimen revealed positive reactivities to Vimentin and S-100 protein. Final diagnosis was made as MPNST.
Keywords
Malignant peripheral nerve sheath tumor; MPNST; Subtotal maxillectomy;
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