Browse > Article

THE CHANGES OF SERUM C-REACTIVE PROTEIN IN THE HEAD AND NECK INFECTION  

Lee, Ju-Hyun (Dept. of Oral and Maxillofacial Surgery, Daegu Fatima Hospital)
Kim, Chin-Soo (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Kyungpook National University)
Lee, Sang-Han (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Kyungpook National University)
Kim, Chul-Hwan (Dept. of Oral and Maxillofacial Surgery, Daegu Fatima Hospital)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.29, no.1, 2003 , pp. 5-13 More about this Journal
Abstract
The purpose of this study is to determine the value of serum concentration of C-reactive protein(CRP) in comparison with ESR and leukocyte as the tools for diagnosis and follow-up study of infection. For this study, thirty-one patients with head and neck infection and thirty-two patients performed the orthognathic surgery were selected for experimental and control groups each other. we analyzed the blood sample daily to measure CRP, ESR and leukocytosis. The results of this study are as the following : 1. Serum C-Reactive Protein levels in the experimental group were higher than control group and the pattern of CRP changes continued to decline in both groups(P<0.001). 2. ESR changes in both groups were scattered without any special pattern. 3. Correlation between CRP and Leukocyte was higher than others(r=0.664, P<0.01). 4. In the Receiver Operating Characteristic(ROC) Curve of experimental group, rapid increase of CRP curve and Area under the curve(AUC) value, 0.774, indicate the high accuracy of estimation. 5. In experimental group, sensitivity of CRP, ESR, and Leukocytosis on recovery day were 83%, 17% and 71%. Based on the results of this study, we could conclude that determination of CRP is more useful method to diagnosis and follow-up study of infection than other commonly used variables in oral and maxillofacial region.
Keywords
C-Reactive Protein(CRP); Head and Neck Infection; Erythrocyte Sedimentation Rate(ESR); Leukocyte;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Krishnan V, Johnson JV, Helfrick JF: Management of maxillofacial infections: A review of 50 cases. J Oral Maxillofac Surg. 1991;51:868-874.   DOI   ScienceOn
2 Tillett WS, Francis T: Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. J Exp Med. 1930;52:561-571.   DOI   PUBMED
3 Berger C, Uehlinger J, Ghelfi D: Comparison of C-reactive protein and white blood cell count with differential in neonates at risk for septicaemia. Eur J Pediatr. 1995;154:138-144.   DOI   ScienceOn
4 Smith RP, Lipworth BJ, Cree IA: C-reactive protein : A clinical marker in community-acquired pneumonia. Chest. 1995;108:1288-1291   DOI   ScienceOn
5 Mayer AD, McMahon MJ, Bowen M: C-reactive protein : an aid to assessment and monitoring of acute pancreatitis. J Clin Pathol. 1984;37:207-211   DOI   PUBMED
6 Clyne B, Olshaker JS: The C-reactive protein. J Emerg Med. 1999;17:1019-1025.   DOI   ScienceOn
7 Fassbender K, Pargger H, Muller W: Interleukin-6 and acute-phase protein concentrations in surgical intensive care unit patients:Diagnostic signs in nosocomial infection. Crit care Med. 1993; 21:1175-1180.   DOI   PUBMED   ScienceOn
8 Fischer CL, Gill C, Forrester MG: Quantitation of acute-phase proteins postoperatively: Value in detection and monitoring of complications. Am J Clin Pathol. 1976;66:840-846.   DOI   PUBMED
9 Lee SY. C-reactive protein: Clinical laboratory medicine, 5th edi. 628
10 Owens WD, Felts JA, Spitznagel EL: ASA physical status classifications:a study of consistency of ratings. Anesthesiology. 1978;49:239-243.   DOI   PUBMED   ScienceOn
11 McCabe WR, Jackson GG: Gram-negative bacteremia. I. Etiology and ecology. Arch Intern Med 1962;110:847-855.   DOI
12 Yen-Watson B, Kushner I: Rabbit CRP response to endotoxin administration: dose dependent relationship and kinetics. Proc Soc Exp Biol Med. 1974;146:1132.
13 Franz AR, Kron M, Pohlandt F: Comparison of procalcitonin with interleukin-8, C-reactive protein and differential white blood cell count for the early diagnosis of bacterial infections in newborn infants. Pediatr Infect Dis J. 1999;18:666-671.   DOI   ScienceOn
14 Dawes PT, Fowler PT, Clarke S: Rheumatoid arthritis: treatment which controls the C-reactive protein and erythrocyte sedimentation rate reduces radiological progression. Br J Rheumatol. 1986;25:44-9.   DOI   PUBMED
15 Anderson HC, McCarty M: The occurrence in the rabbit of an acute phase protein analogous to human C-reactive protein. J Exp Med. 1951;93:25.
16 Terregino CA, Lopez BL, Karras DJ: Endogenous Mediators in emergency department patients with presumed sepsis: Are levels associated with progression to severe sepsis and death? Ann. Emerg. Medi. 2000;35:26-34.
17 Pittet D, Rangel-Frausto S, Li N: Systemic inflammatory respose syndrme, sepsis, severe sepsis, and septic shock: incidence, morbidities, and outcomes in surgical ICU patients. Inten Care Med. 1995;21:302-309.   DOI
18 Pepys MB : C-reactive protein fifty years on. Lancet. 1981;1:653-656.   PUBMED
19 Grondinsky M, Holyoke EA: The fasciae and fascial spaces of the head and adjacent region. Am J Anat. 1938;63:367.
20 Iizuka T, Lindqvist C: Changes in C-reactive protein associated with surgical treatment of mandibular fractures. J Oral Maxillofac Surg. 1991;49:464-467.   DOI   ScienceOn
21 Ylijoki S, Suuronen R, Jousimies-Somer H: Differences between patients with or without the need for intensive care due to severe odontogenic infections. J Oral Maxilofac Surg. 2001;59:867-872.   DOI   ScienceOn
22 Young B, Gleeson M, Cripps AW: C-reactive protein: A critical review. Pathology. 1991;23:118-124.   DOI   ScienceOn
23 Du Clos TW: Function of C-reactive protein. Ann Med. 2000;32:274-278.   DOI   PUBMED   ScienceOn
24 Haug RH, Hoffman MJ, Indresano AT: An epidemiologic and anatomic survey of odontogenic infections. J Oral Maxillofac Surg. 1991;49:976-982.   DOI   ScienceOn
25 Mustard RA Jr, Bohnen JMA, Haseeb S: C-reactive protein levels predict postoperative septic complications. Arch Surg. 1987;122:69-73   DOI   PUBMED   ScienceOn
26 Saarinen UM, Strandjord SE, Warkentin PI: Differentiation of presumed sepsis from acute graft-versus-host-disease by C-reactive protein and serum total IgE in bone marrow transplant recipients. Transplantation. 1987;44:540-6.   DOI   PUBMED   ScienceOn
27 Gewurz H, Mold C, Siegel J: C-reactive protein and the acute phase response. Adv Int Med. 1982;27:345-372.
28 Williams, Wilkins: American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20(6):864-874.   DOI   ScienceOn
29 Peters ES, Fong B, Wormuth DW: Risk factors affecting hospital length of stay in patients with odontogenic maxillofacial infections. J Oral Maxillofac Surg. 1996;54:1386-1391.   DOI   ScienceOn
30 Young EW, Johnson WT, Lundin R: Evaluation of treatment provided patients hospitalized with orofacial odontogenic infection: A retrospective study. Oral Surg Oral Med Oral Pathol. 1985;59:28-33.   DOI   ScienceOn
31 El Hassan BS, Peak JD, Whicher J: Acute phase protein levels as an index of severity of physical injury. Int J Oral Maxillofac Surg. 1990;19:346-349.   DOI   ScienceOn
32 Dawson JB: A simple, standard, erythrocyte sedimentation rate. Lab Med. 1972;35-37.
33 Reny JL, Vuagnat A, Ract C: Diagnosis and follow-up of infections in intensive care patients: Value of C-reactive protein compared with other clinical and biological variables. Crit Care Med. 2002;30:529-535.   DOI   ScienceOn
34 Knaus WA, Draper EA, Wagner DP: Apache II: a severity of disease classification system. Crit Care Med. 1985;13:818-829.   DOI   PUBMED   ScienceOn
35 povoa P, Almeida E, Moreira P: C-reactive protein as an indicator of sepsis. Inten Care Med. 1998;24:1052-1056.   DOI   ScienceOn
36 Kim ID, Lee SY, Kim PT: A diagnostic value of C-reactive protein in acute bacterial infection of bone and joint. J of Korean Orthop Assoc. 1986;21:39-46.
37 Evans MI, Hajj SN, Devoe LD: C-reactive protein as a predictor of infectious morbidity with premature rupture of membranes. Am J Obstet Gynecol. 1980;13:648-652.