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CORRELATION OF METASTASIS AND PROGNOSTIC FACTORS IN SQUAMOUS CELL CARCINOMA OF HEAD AND NECK  

Seo, Gu-Jong (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dental Science Research Institute, Chonnam National University)
Ryu, Sun-Youl (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dental Science Research Institute, Chonnam National University)
Kim, Ok-Joon (Department of Oral Pathology, College of Dentistry, Dental Science Research Institute, Chonnam National University)
Choi, Hong-Ran (Department of Oral Pathology, College of Dentistry, Dental Science Research Institute, Chonnam National University)
Publication Information
Journal of the Korean Association of Oral and Maxillofacial Surgeons / v.28, no.1, 2002 , pp. 7-15 More about this Journal
Abstract
The present study was carried out to evaluate the correlation of metastasis and prognostic factors in squamous cell carcinoma of head and neck. Examination was performed on a series of thirty-seven patients who were confirmed to squamous cell carcinoma and its lymphatic metastasis by pathologist. Correlations of metastasis and other factors such as angiogenesis, histologic grading, and p53 expression and ras oncogene were studied. The depth of tumors was around 1 to 27mm. Twenty cases were more than 10mm deep, of which seventeen cases were shown lymphatic metastasis. Total score of histologic grading including keratinization, nuclear atypia, growth pattern and intensity of inflammation was ranged from 5 to 10 points. Of these factors, nuclear atypia with intensity of inflammation, and nuclear atypia with growth pattern was correlated with nuclear atypia each. For angiogenesis, number of new-formed vessels were counted 13 to 58 each. Twenty-eight cases were shown to lymphatic metastasis. No correlation with histologic grading and lymphatic metastasis was found. The results of immunohistochemical staining for p53 and ras oncogene revealed that positive cases were 16 and 22, negative for 21 and 15 each. However, both were not correlated with histologic grading and lymphatic metastasis. These results were revealed that angiogenesis was not correlated with lymphatic metastasis of squamous cell carcinoma arising in head and neck. Nuclear atypia with intensity of inflammation and dysplasia with growth pattern were correlated with histologic grading, which suggested that more careful and adequate advice is needed for effective treatment.
Keywords
Prognostic factors; Metastasis; Squamous cell carcinoma; Head and neck;
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