Browse > Article
http://dx.doi.org/10.14476/jomp.2020.45.2.39

Pediatric Non-Infectious Osteomyelitis of the Mandible: A Case Report  

Lee, Kyu-Hoon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University)
Moon, Seong-Yong (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University)
You, Jae-Seek (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University)
Kim, Gyeong-Mi (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University)
Lee, Nan-Young (Department of Pediatric Dentistry, School of Dentistry, Chosun University)
Oh, Ji-Su (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University)
Publication Information
Journal of Oral Medicine and Pain / v.45, no.2, 2020 , pp. 39-43 More about this Journal
Abstract
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare idiopathic inflammatory bone disease characterized by pain and swelling without any detectable infectious factors, the main feature is mild to moderate bone pain. CRMO commonly develops in the metaphyses of long bones and clavicles in children or adolescents. Chronic nonbacterial osteomyelitis (CNO) is the isolated form of CRMO and the etiology of CNO is still unclear. This report describes a rare case of CNO of the mandible in an 8-year-old female patient. On the basis of clinical, histological, and radiological findings, CNO was diagnosed. The patient was asymptomatic after surgical curettage followed by antibiotic therapy. Cone beam CT scan revealed a nearly completed bone healing after three months.
Keywords
Chronic recurrent multifocal osteomyelitis; Jaw diseases; Mandible; Osteomyelitis;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Simm PJ, Allen RC, Zacharin MR. Bisphosphonate treatment in chronic recurrent multifocal osteomyelitis. J Pediatr 2008;152:571-575.   DOI
2 Giedion A, Holthusen W, Masel LF, Vischer D. [Subacute and chronic “symmetrical” osteomyelitis]. Ann Radiol (Paris) 1972;15:329-342.
3 Chen Z, Cheng L, Feng G. Bone inflammation and chronic recurrent multifocal osteomyelitis. Eur Rev Med Pharmacol Sci 2018;22:1380-1386.
4 Padwa BL, Dentino K, Robson CD, Woo SB, Kurek K, Resnick CM. Pediatric chronic nonbacterial osteomyelitis of the jaw: clinical, radiographic, and histopathologic features. J Oral Maxillofac Surg 2016;74:2393-2402.   DOI
5 Wipff J, Costantino F, Lemelle I, et al. A large national cohort of French patients with chronic recurrent multifocal osteitis. Arthritis Rheumatol 2015;67:1128-1137.   DOI
6 Girschick HJ, Raab P, Surbaum S, et al. Chronic non-bacterial osteomyelitis in children. Ann Rheum Dis 2005;64:279-285.   DOI
7 Monsour PA, Dalton JB. Chronic recurrent multifocal osteomyelitis involving the mandible: case reports and review of the literature. Dentomaxillofac Radiol 2010;39:184-190.   DOI
8 Kim SM, Lee SK. Chronic non-bacterial osteomyelitis in the jaw. J Korean Assoc Oral Maxillofac Surg 2019;45:68-75.   DOI
9 Roderick MR, Shah R, Rogers V, Finn A, Ramanan AV. Chronic recurrent multifocal osteomyelitis (CRMO) - advancing the diagnosis. Pediatr Rheumatol Online J 2016;14:47.   DOI
10 Girschick HJ, Huppertz HI, Harmsen D, Krauspe R, Muller-Hermelink HK, Papadopoulos T. Chronic recurrent multifocal osteomyelitis in children: diagnostic value of histopathology and microbial testing. Hum Pathol 1999;30:59-65.   DOI
11 Hummell DS, Anderson SJ, Wright PF, Cassell GH, Waites KB. Chronic recurrent multifocal osteomyelitis: are mycoplasmas involved? N Engl J Med 1987;317:510-511.
12 Gleeson H, Wiltshire E, Briody J, et al. Childhood chronic recurrent multifocal osteomyelitis: pamidronate therapy decreases pain and improves vertebral shape. J Rheumatol 2008;35:707-712.
13 Borzutzky A, Stern S, Reiff A, et al. Pediatric chronic nonbacterial osteomyelitis. Pediatrics 2012;130:e1190-e1197.   DOI
14 Rasmussen AQ, Andersen UB, Jorgensen NR, Schwarz P. Noninfectious osteomyelitis of the mandible in a young woman: a case report. J Med Case Rep 2014;8:44.   DOI
15 Miettunen PM, Wei X, Kaura D, Reslan WA, Aguirre AN, Kellner JD. Dramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J 2009;7:2.   DOI
16 Job-Deslandre C, Krebs S, Kahan A. Chronic recurrent multifocal osteomyelitis: five-year outcomes in 14 pediatric cases. Joint Bone Spine 2001;68:245-251.   DOI
17 Hedrich CM, Hofmann SR, Pablik J, Morbach H, Girschick HJ. Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J 2013;11:47.   DOI
18 Compeyrot-Lacassagne S, Rosenberg AM, Babyn P, Laxer RM. Pamidronate treatment of chronic noninfectious inflammatory lesions of the mandible in children. J Rheumatol 2007;34:1585-1589.