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http://dx.doi.org/10.14476/jomp.2019.44.1.1

Evaluation of Clinically Effective Doses of Triamcinolone Acetonide for Intralesional Injection in Oral Lichen Planus  

Park, Su-Hyeon (Department of Oral Medicine, Dental Research Institute, Institute of Translational Dental Sciences, School of Dentistry, Pusan National University)
Lee, Hae-Ohk (Department of Oral Medicine, Dental Research Institute, Institute of Translational Dental Sciences, School of Dentistry, Pusan National University)
Ju, Hye-Min (Department of Oral Medicine, Dental Research Institute, Institute of Translational Dental Sciences, School of Dentistry, Pusan National University)
Lee, Ji-Yeon (Department of Oral Medicine, Dental Research Institute, Institute of Translational Dental Sciences, School of Dentistry, Pusan National University)
Jeon, Hye-Mi (Department of Oral Medicine, Pusan National University Hospital)
Ok, Soo-Min (Department of Oral Medicine, Dental Research Institute, Institute of Translational Dental Sciences, School of Dentistry, Pusan National University)
Ahn, Yong-Woo (Department of Oral Medicine, Dental Research Institute, Institute of Translational Dental Sciences, School of Dentistry, Pusan National University)
Jeong, Sung-Hee (Department of Oral Medicine, Dental Research Institute, Institute of Translational Dental Sciences, School of Dentistry, Pusan National University)
Publication Information
Journal of Oral Medicine and Pain / v.44, no.1, 2019 , pp. 1-10 More about this Journal
Abstract
Purpose: The aim of this study was to evaluate the optimal doses of intralesional triamcinolone acetonide (TA) in the treatment of oral lichen planus (OLP). Methods: A randomized clinical trial was performed. Sixty-two lesions of OLP were received 12 mg (group A) or 20 mg (group B) of TA intralesionally weekly for 2 weeks. Subjective symptoms, lesion size, favorable conversion of clinical subtypes, and clinical response were evaluated at weeks 0, 1, 2, and 4. Results: After two consecutive injections of TA, group B showed significant reduction in burning sensation and reticular area (p<0.01). Favorable conversion and complete response were greater in group B. Mild oral candidiasis was developed in group B (10.7%). Conclusions: A 20-mg injection of TA was much more effective compared with 12-mg injection of TA in the treatment of OLP.
Keywords
Intralesional injections; Oral lichen planus; Triamcinolone acetonide;
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