Browse > Article

Detection of Helicobacter pylori in Saliva of Patient with Oral Lichen Planus  

Ryu, Ji-Won (Department of Oral Medicine, College of Dentistry, Chosun University)
Kang, Seung-Woo (Department of Oral Medicine, College of Dentistry, Chosun University)
Yoon, Chang-Lyuk (Department of Oral Medicine, College of Dentistry, Chosun University)
Ahn, Jong-Mo (Department of Oral Medicine, College of Dentistry, Chosun University)
Publication Information
Journal of Oral Medicine and Pain / v.33, no.3, 2008 , pp. 241-246 More about this Journal
Abstract
Lichen planus is a common, chronic inflammatory disease of the skin and mucous membrane for which no precise causes have been confirmed. But it is often connected with infections. Helicobacter pylori(H. pylori) among various bacteria has been associated with the cause of gastritis, peptic ulcer and gastric cancer. Considering the similarities of histological features between gastric ulcer and oral ulcers, it is resonable to assume that H. pylori might also be involved in the development oral mucosal ulceration. So we employed this study to investigate the possible involvement of H. pylori in the aetiology of erosive oral lichen planus. We analyzed detection rate of H. pylori in saliva of patients with erosive oral lichen planus by nested PCR. As a result, it revealed a significant difference statistically by showing positivity in 16 to 21(76.2%) saliva samples of patients group and in 11 of 44(25%) saliva samples of control group(P>0.001). We were able to suppose that H. pylori in saliva can be related to cause of erosive oral lichen planus.
Keywords
Erosive oral lichen planus; Helicobacter pylori; saliva;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Czesnikiewicz-Guzik M, Karczewska E, Bielonski W. Association of the presence of Helicobacter pylori in the oral cavity and in the stomach. J Physiol Pharmacol 2004;15:187-194
2 Sanli H, Cetinkaya H, Tursen U, Kaya M, Kuzu I, Gurler A. Upper gastrointestinal findings in oral lichen planus. Turk J Gastroentrol 2002;13(1):31-34
3 Bussac G. Helicobacter pylori and the oral environment. Practical periodontics and aesthetic dentistiry 1999;11(8):918-922
4 Leimola-Virtanen R, Happonen RP, Syrjanen S. Cytomegalovirus (CMV) and Helicobacter pylori (HP) found in oral mucosal ulcers. J Oral Pathol Med 1995;24(1):14-17   DOI   ScienceOn
5 Kang SW, Yoon CL, Ahn JM, Lee HJ, Hur W. Effect of vomiting in the intraoral incidence of Helicobacter pylori. Korean J Oral Med 2003;28(4):447-453
6 Song Q, Spahr A, Schmid RM, Adler G, Bode G. Helicobacter pylori in the oral cavity : high prevalence and great DNA diversity. Dig Dis Sci 2000;45(11):2162-2167   DOI   ScienceOn
7 Riggio MP, Lennon A, Wray D. Detection of Helicobacter pylori DNA in recurrent aphthous stomatitis tissue by PCR. J Oral Pathol Med 2000;29(10):507-513   DOI   ScienceOn
8 Birek C, Grandhi R, McNeill K, Singer D, Ficarra G, Bowden G. Detection of Helicobacter pylori in oral pahthous ulcers. J Oral Pathol Med 1999;28(5):197-203   DOI   ScienceOn
9 Andersen RN, Ganeshkumar N, Kolenbrander PE. Helicobacter pylori adheres selectively to Fusobacterium spp. Oral Microbiol Immunol 1998;13:51-54   DOI   ScienceOn
10 Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, Lsaacson PG. Helicobacter pylori-associated gastritis and primary B-cell gastic lymphoma. Lancet 1991;338:1175-1176   DOI   ScienceOn
11 Shimoyama T, Horie N, Kato T, Kaneko T, Komiyama K. Helicobacter pylori in oral ulceration. J Oral Sci 2000;42(4):225-229   DOI   ScienceOn
12 Tytgat GN, Noach LA, Rauwa EA. Helicobacter pylori infection and deuodenal ulcer disease. Gastroenterol Clin North Am 1993;22:127-139
13 Li C, Musich PR, Ha T et al. High prevalence of Helicobacter pylori in saliva demonstrated by a novel PCR assay. J Clin Pathol 1995;48(7):662-666   DOI
14 Veerman EC, Bank CN, Namavar F, Appelmelk BJ, Bolscher JG, Nieuw Amerongen AV. Sulfated glycans on oral mucin as receptors for Helicobacter pylori. Glycobiology 1997;7(6):737 -743   DOI   ScienceOn
15 Laskaris G. Color Atlas of Oral Disease. New York, 1988, Thieme Medical Publishers, Inc., pp.184-186
16 Dauden E, Cabrero MM, Onate MJ, Pajares JM, Garcia-Dlez A. Helicobacter pylori Cag A seropositivity is not strongly associated with lichen planus. J Am Acad Dermatol 2003;49(6):1199
17 Dowsett SA, Kowolik MJ. Oral Helicobacter pylori : Can we stomach it ? Crit Rev Oral Biol Med 2003;14:226-233   DOI
18 Vainio E, Huovinen S, Liutu M, Uksila J, Leino R. Peptic ulcer and Helicobacter pylori in patients with lichen planus. Acta Derm Venereol 2000;80(6):427-429   DOI
19 Long BJ, Chen K, Wu BL, Duan JM. Detection of Helicobacter pylori in oral cavity of patients with recurrent aphthous ulcer. Nan Fang Yi Ke Da Xue Xue Bao 2007;27(4):477-478
20 Westblom TU. Molecular diagnosis of Helicobacter pylori. Immunol Invest 1997;26:163-174   DOI
21 Lamaroon A, Chaimano S, Linpisarn S, Pongsiriwet S, Phornphutkul K. Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR. J Oral Sci 2003;45(2):107 -110   DOI   ScienceOn