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Effects of Zinc on Oral Bacteria and Volatile Sulfur Compound (VSC) in Oral Cavity  

Kim, Young-Jun (Department of Oral Medicine and Diagnosis, College of Dentistry, Kangnung National University)
Publication Information
Journal of Oral Medicine and Pain / v.32, no.3, 2007 , pp. 273-281 More about this Journal
Abstract
Zinc compounds have been used in various fields - cosmetics, medicine, and dentistry -because of its effective functions to human tissues or organs. Especially, it is well known that zinc has many biologic effects in oral cavity. Zinc ion can affect various oral microorganisms, resulting in reduction of oral bacteria, dental plaque, and dental caries. Also, zinc ion has an ability to reduce amounts of oral anaerobic bacteria and oral VSC and can reduce oral malodor. The author summarized the characteristics and toxicity of zinc, several forms of zinc compounds applied in human tissues, and reviewed biologic effects of Zinc in oral cavity (anti-bacterial effects, anti-plaque effects, anti-caries effects, and anti-VSC effects of zinc). Because of many advantages of zinc in oral cavity, it can be concluded that application of zinc compound to various oral diseases will be extended and activated, and promising.
Keywords
Zinc; Anti-bacterial effect; Anti-plaque effect; Anti-caries effect; Volatile sulfur compound; Oral malodor;
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  • Reference
1 Afseth J. Some aspects of the dynamics of Cu and Zn retained in plaque as related to their effects on plaque pH. Scand J Dental Res 1983;91:169-174
2 Giertsen E, Scheie AA, Rolla G : Dose-related effects of $ZnCl_2$ on dental plaque formation and plaque acidogenicity in vivo. Caries Res 1989;23:272-277   DOI   ScienceOn
3 Saxton CA, Lane RM, van der Ouderaa FJG. The effects of a dentifrice containing a zinc salt and a non-cationic antimicrobial agent on plaque and gingivitis. J Clin Periodontol 1987;14:144-148   DOI
4 Jenkins S, Addy M, Newcocombe R. Studies on the effect of toothpaste rinses on plaque regrowth. J Clin Periodontol 1989;16:385-387   DOI
5 Gallagher IHC, Cutress TW. The effect of trace elements on the growth and fermentation by oral streptococci and Actinomyces. Arch Oral Biol 1977;22:555-562   DOI   ScienceOn
6 Waler SM. Effect of some metal ions on volatile sulfur containing compounds originating from the oral cavity. Acta Odontol Scand 1997;55:261-264   DOI   ScienceOn
7 Schmidt NF, Tarbet WJ. The effect of oral rinse on organoleptic mouth odor ratings and levels of VSCs. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1978;45:876-883   DOI
8 Loesche WJ, Kazor C. Microbiology and treatment of halitosis. Periodontology 2002;28:256-279   DOI   ScienceOn
9 Raven SJ, Matheson JR, Huntington E, Tonzetich J. The efficacy of a combined zinc and triclosan system in the prevention of oral malodour. In van Steenberghe D, Rosenberg M (Ed). Bad breath: a multidisciplinary approach. Leuven,1996, Leuven University Press, pp. 241-254
10 Remington's Practice of pharmacology. 9th ed., 1948, The Mack Publishing Company, pp.416-421
11 Maryanski JH, Wittenberger CL. Mannitol transport in Streptococcus mutans. J Bacteriol 1975;124:1475-1481
12 Li J, Ellen RP. Contribution of protease of Bacteroides gingivalis to its adhesion to Actinomyces viscosus. J Dental Res 1990;69:Abstr.no. 257
13 Gedalia I. Effect of $ZnCl_2$ mouthwash on plaque and zinc level of surface enamel. Clin Prev Dent 1988;10:3-5
14 He G, Pearce EIF, Sisson CH. Inhibitory effect of ZnCl2 on glycolysis in human oral microbes. Arch Oral Biol 2002;47:117-129   DOI   ScienceOn
15 Niles HP, Gaffar A. Advances in mouth odor research. In: Rosenberg M (Ed). Bad breath: research perspectives. Tel Aviv, 1995, Ramot Publishing, pp. 55-70
16 Jonski G, Young A, Waler SM, Rolla G. Insoluble zinc, cupric and tin pyrophosphate inhibit the formation of volatile sulfur compounds. Eur J Oral Sci 2004;112:429-432   DOI   ScienceOn
17 Oppermann RV, Rolla G, Johansen HR, Assev S. Thiol groups and reduced acidogenicity of dental plaque in the presence of metal ions in vivo. Scand J Dent Res 1980;88:389-396
18 Afseth J, Oppermann RV, Rolla G. The in vivo effect of glucose solutions containing Cu2+ and Zn2+ on the acidogenicity of plaque. Acta Odontol Scand 1980;38: 229-233   DOI   ScienceOn
19 Young A, Jonski G, Rolla G, Waler SM. Effects of metal salts on the oral production of volatile sulfurcontaining compounds (VSC). J Clin Periodontol 2001;28;776-781   DOI   ScienceOn
20 Page DJ. Concentration of antimicrobial proteins in human saliva. Caries Res 1990;24:216-219   DOI   ScienceOn
21 Cummins D. zinc citrate/Triclosan : a new anti-plaque system for the control of plaque and the prevention of gingivitis: short-term clinical and mode of action studies. J Clin Periodontol. 1991;18(6):455-461   DOI
22 Watson GK, Cummins D, van der Ouderaa FJG. Inhibition of acid production by Streptococcus mutans NCTC10449 by zinc and the effect of metal speciation. Caries Res 1991;25:431-437   DOI   ScienceOn
23 Thylstrup A, Fejerskov O. Textbook of clinical cariology. 2nd ed., Copenhagen, 1994, Munksgaard textbook, pp.74-75
24 Rolla G, Jonski G, Young A. The significance of the source of zinc and its anti-VSC effect. Int Dent J 2002;52:233-235   DOI
25 Mattew JE. Medical Toxicology. 1988, Elsevier Science Publishing Company, pp.1064-1065
26 Klotz IM. Thermodynamic and molecular properties of some metal-protein complex. In Mcelroy WD, Glass B. The mechanism of enzyme action. Baltimore, 1954, Johns Hopkins Press, pp. 257-285
27 Waler SM. The effect of zinc containing chewing gum on VSC in the oral cavity. Acta Odontol Scand 1997;55:198-200   DOI   ScienceOn
28 van Steenberghe D, Avontroodt P et al.. Effect of different mouthrinses on morning breath. J Periodontol 2001;72:1183-1191   DOI   ScienceOn
29 Young A, Jonski G, Rolla G. Inhibition of orally produced volatile sulfur compounds by zinc, chlorhexidine or cetylpyridinium chloride effect of concentration. Eur J Oral Sci 2003;111:400-404   DOI   ScienceOn
30 Harrap GJ. Inhibition of plaque growth by zinc salts. J Periodontal Res 1983;8:634-642
31 Cummins D, Watson GK. Computer model relating chemistry to biological activity of metal anti-plaque agents. J Dental Res 1989; 68:1702-1705
32 Jones CL, Stephen KW, Ritchie JA, Huntington E, Saxton CA, van der Ouderaa FJG. Long-term exposure of plaque to zinc citrate. Caries Res 1988;22:84-90   DOI   ScienceOn
33 The Merk Index. 12th ed., 1996, Merk & CO., Inc., pp. 10251-10294
34 Lee SG, Kim ES, Lee SW. Effects of Zinc containing solution on oral microorganisms. Kor J Oral Med 1999;23:343-352
35 Krespi YP, Shrime MG, Kacker A. The relationship between oral malodor and volatile sulfur compoundproducing bacteria. Otolaryngology-Head and Neck Surgery 2006;135:671-676   DOI   ScienceOn
36 Oppermann RV, Rolla G. Effect of some polyvalent cations on the acidogenicity of dental plaque in vivo. Caries Res 1980;14:422-427   DOI   ScienceOn
37 Jones CL, Purdell-Lewis D, van der Ouderaa FJG. The effect of zinc citrate on oral bacteria in continuous culture. J Dent Res 1988;67:Abstr. No. 1713
38 Quirynen M, Zhao H, van Steenberghe D. Review of the treatment strategies for oral malodour. Clin Oral Invest 2002;6:1-10
39 Young A, Jonski G, Rolla G. The oral anti-volatile sulphur compound effects of zinc salts and their stability constants. Eur J Oral Sci 2002;110:31-34   DOI   ScienceOn
40 Giertsen E, Scheie AA, Rolla G. Inhibition of plaque formation and plaque acidogenicity by zinc and chlorhexidine combinations. Scand J Dental Res 1988;96:541-550
41 Keevil CW, Williamson MI, Marsh PD, Elwood DC. Evidence that glucose and sucrose uptake in oral streptococcal bacteria involves independent phosphotransferase and proton-motive force-mediated mechanisms. Arch Oral Biol 1984;29:871-878   DOI   ScienceOn
42 Tonzetich J, Ng SK. Reduction of malodor by oral cleansing procedures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1976;42:172-181   DOI
43 Willet NP, White RR, Rosen S. Essential dental microbiology. Connecticut, 1991, Appleton & lange, pp. 28-29