Browse > Article

Detection of Herpes Simplex Virus, Varicella Zoster Virus, Helicobacter Pylori and Candida in Saliva of Patients with Recurrent Aphthous Ulceration  

Hur, Woong (Department of Oral Medicine, Institute of Forensic Odontology, College of Dentistry, Chosun University)
Yoon, Chang-Lyuk (Department of Oral Medicine, Institute of Forensic Odontology, College of Dentistry, Chosun University)
Ahn, Jong-Mo (Department of Oral Medicine, Institute of Forensic Odontology, College of Dentistry, Chosun University)
Publication Information
Journal of Oral Medicine and Pain / v.30, no.3, 2005 , pp. 319-328 More about this Journal
Abstract
To examine whether HSV, VZV, H. pylori and Candida that are known to be microorganisms causing ulcerative disease in oral cavity and have the relatively high contigiousness are detected in saliva of patients with RAU and related to the development with RAU, PCR and culture were performed on the saliva of 29 patients with RAU and 29 control subjects who visited the Department of Oral Medicine, Dental Hospital, Chosun University. The results were obtained as follows; 1. HSV DNA was detected in 41.4% patients with RAU, and 55.2% control subjects, however, a significant difference between the two groups was not detected, (P>0.05), and VZV DNA was not detected in both groups. 2. H. pylori DNA was detected in 27.6% patients with RAU, and 48.3% control subjects, however, a significant difference between the two groups was not detected (P>0.05). 3. Candida was cultured in 13.8% patients with RAU, and 6.9% control subjects, however, a significant difference between the two groups was not detected (P>0.05). This results suggest that HSV, VZV, H. pylori and Candida can not be regarded to play a direct role in the development of RAU. Thus it is considered that in future, on a larger sample, also, it has to be examined whether other microorganisms acts as a trigger factor of the development of RAU.
Keywords
Recurrent aphthous ulcer; HSV; VZV; H. pylori; Candida;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Park SB, Kim BG, Bae JS. Detection of viruses and changes of protein of saliva in patients with recurrent aphthous ulcer. J Kor Acad Oral Med 1999;24(2): 125-135
2 Brice SL, Cook D, Leahy H, Huff JC, Weston WL. Examination of the oral mucosa and peripheral blood cells of patients with recurrent aphthous ulceration for human herpesvirus DNA. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89(2):193-198   DOI   ScienceOn
3 Sciubba JJ. Herpes simplex and aphthous ulceration : presentation, diagnosis and management an update. Gen Dent 2003;51(6):510-516
4 Ramos-Gomez F. Dental corsiderations for the paediatric AIDS/HIV patient. Oral Dis 2002;2(8): 49-54
5 Galliani EA, Infantolino D, Tarantello M, Cipriani R, De Lazzari F. Recurrent aphthous stomatitis: which role for viruses, food, and dental materials? Ann Ital Med Int 1998;13(3):152-156
6 Narikawa S, Suzuki Y, Takahashi M et al. Streptococcus oralis previously identified as uncommon 'streptococcus sanguis' in Béhçet's disease. Arch Oral Biol 1995;40(8):685-690   DOI   ScienceOn
7 Vidoria JM, Kalopothakis E, Silva JdeF, Gomez RS. Helicobacter pylori DNA in recurrent aphthous stomatitis. J Oral Pathol Med 2003;32(4):219-223   DOI   ScienceOn
8 Shames B, Krajden S, Fuksa M, Babida C, Penner JL. Evidence fot the occurrence of the same strain of Campylobacter pylori in the stomach and the dental plaque. J Cli Microbiol 1989;27(12):2849-2850
9 Fritscher AM, Cherubini K, Chies J, Dias AC. Association between Helicobacter pylori and recurrent aphthous stomatitis in children and adolescents. J Oral Pathol Med 2004;33(3):129-132   DOI   ScienceOn
10 Iamaroon A, Chaimano S, Linpisan S, Pangsiriwet S, Phomphutkul K. Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR. J Oral Sci 2003;:107-110
11 Oudshoorn AH, Ramaker C. Stomatitis in childhood, not always benign. Ned Tijdschr Geneeskd 2000;(2): 1985-1990
12 Kim HC, Kim JH, Lee SS et al. Incidence of Helicobacter pylori detected by PCR and its relation to the potential etiology of recurrent aphthous ulcerations. J Kor Acad Oral Med 2002;27(4):401-413
13 Dowsett SA, Kowolik M. Oral Helicobacter pylori: Can we stomach it? Crit Rew Oral Biol Med 2003;14(3):226-233   DOI   ScienceOn
14 Lee S, Bang D, Cho YH, Lee ES, Sohn S. Polymerase chain reaction reveals herpes simplex virus DNA in saliva of patients with Béhçet's disease. Arch Dermatol Res 1996;288:179-183   DOI   ScienceOn
15 Pavelic J, Gall-Troselj K, Jurak I, Mravak-Stipetic M. Helicobacter pylori in oral aphthous ulcers. J Oral Pathol Med 2000;29:523-525   DOI   ScienceOn
16 Gileva O, Sazhina H, Gileva E, Efimov A, Scully C. Spectrum of oral manifestation of HIV/AIDS in the perm region (Russia) and identification of self-induced ulceronegotic lingual lesions. Med Oral 2004;9(3):212-215
17 Shimoyama T, Horie N, Kato T, Kaneko T, Komiyama K. Helicobacter pylori in oral ulcerations. J Oral Sci 2000;42(4):225-229   DOI   ScienceOn
18 Di Luca D, Mirandola P, Ravaioli T et al. Human herpesvirus 6 and 7 in salivary glands and shedding in saliva of healthy and human immunodeficiency virus positive individuals. J Med Virol 1995;45(4):462-468   DOI   ScienceOn
19 Regezi JA, Sciubba J. Ulceration conditions. In Oral pathology Clinical-pathologic correlations edited by Regezi JA, Sciubba J, Philadelphia, 1999, WB Saunders, 46-53
20 Richter J, Grimmova M, Stiborova I, Kral V, Jeilek D. Detection of Helicobacter pylori in the saliva of patients with recurrent apthous stomatitis. Cas Lek Cesk 2003;142(11):665-669
21 Studd M, McCance DJ, Lehner T. Detection of HSV-1 DNA in patients with Béhçet's syndrome and in patients with recurrent oral ulcers by the polymerase chain reaction. J Med Microbiol 1991;34:39-43   DOI   PUBMED
22 Pedersen A. Are recurrent oral aphthous ulcers of viral etiology? Med Hypotheses 1991;36(3):206-210   DOI   PUBMED   ScienceOn
23 Donatsky O, Justensen T, Lind K, Vestergaard BF. Microorganism in recurrent aphthous ulcerations. Scand J Dent Med 1977;85(6):426-433
24 Riggio MP, Lennon A, Ghodratnama F, Wray D. Lack of association between streptococcus oralis and recurrent aphthous stomatitis. J Oral Pathol Med 2000;29(1):26-32   DOI   ScienceOn
25 Pedersen A, Hornsleth A. Recurrent aphthous ulceration: a possible clinical manifestation of reactivation of varicella zoster or cytomegalovirus infection. J Oral Pathol Med 1993;22(2):64-68   DOI   ScienceOn
26 Goodwin CS, Mendall MM, Northfield TC. Helicobacter pylori infection. Lancet 1999;349: 265-269
27 Safronova LA, Poltavs'kyi OM, Tsaruk'janova IH et al. Oral cavity microbial coenobia in healthy children and childre with chronic recurrent aphthous stomatitis. Mikrobiol Z 2003;65(6):49-58
28 Briek C, Grandhi R, McNeil K et al. Detection of Helicobacter pylori in oral aphthous ulcers. J Oral Pathol Med 2000;29(10):523-525   DOI   ScienceOn
29 Ghodratnama F, Riggio MP, Wray D. Search for human herpesvirus 6, human cytomegalovirus and varicella zoster virus DNA in recurrent aphthous stomatitis tissue. J Oral Pathol Med 1997;26(4): 192-197   DOI   ScienceOn
30 Embil JA, Stephens RG, Manuel FR. Prevalence of recurrent herpes labialis and aphthous ulcers among young adults on six continents. J Can Med Assoc 1975;113 627-630
31 Mandel ID. The function of saliva. J Dent Res 1987;66:623-627   DOI
32 Hoover CI, Olson JA, Greenspan JS. Humoral responses and cross-reactivity to viridans streptococci in recurrent aphthous ulceration. J Dent Res 1986;65(8):1101-1104   DOI   ScienceOn