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Microstructural Changes after Intramuscular Injection of Lidocaine and Dexamethasone  

Jang, Seong-Min (Department of Oral Medicine, Institution of Oral Bioscience, College of Dentistry, Chonbuk National University)
Lee, Kyong-Eun (Department of Oral Medicine, Institution of Oral Bioscience, College of Dentistry, Chonbuk National University)
Publication Information
Journal of Oral Medicine and Pain / v.30, no.1, 2005 , pp. 25-34 More about this Journal
Abstract
A trigger point injection (TPI) has been reported to have an immediate analgesic effect, and to be one of the most widely employed treatment methods of myofascial pain. There are normal saline, local anesthetics, and steroids as the solutions frequently used in TPI. They can be used separately or in combination. Local anaesthetics have myotoxicity in proportion to its concentration. The purpose of this study was to evaluate microstructural changes in point of the myotoxic effects of the combined solution of lidocaine and dexamethasone (a local anesthetic and a steroid) after being injected into the muscle of BALB/c mice. And this study tested solutions with various concentration separately and in combination, to find out proper concentration of solution without muscular tissue damage. This study shows that lidocaine and dexamethasone combination is not histologically myotoxic in case of the concentration of lidocaine less than 1.5%. Also it is suggested from this study that this combined solution will have an analgesic and anti-inflammatory effect. Hereafter continuous study should be performed to reveal that these results can be applied to human when lidocaine and dexamethasone combination is used as an injection modality of TrP treatment.
Keywords
myofascial pain; trigger point injection; dexamethasone; lidocaine;
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