Browse > Article
http://dx.doi.org/10.5536/KJPS.2013.40.2.083

Association of SNPs from iNOS and TLR-4 Genes with Economic Trait in Chicken  

Lim, Hee Kyong (Genomic Informatics Center, Hankyong National University)
Han, Jung-Min (Genomic Informatics Center, Hankyong National University)
Oh, Jae Don (Genomic Informatics Center, Hankyong National University)
Lee, Hak Kyo (Genomic Informatics Center, Hankyong National University)
Jeon, Gwang Joo (Genomic Informatics Center, Hankyong National University)
Lee, Jun Heon (Department of Animal Science and Biotechnology, Chungnam National University)
Seo, Dong Won (Department of Animal Science and Biotechnology, Chungnam National University)
Cahyadi, Muhammad (Department of Animal Science and Biotechnology, Chungnam National University)
Song, Ki Duk (Genomic Informatics Center, Hankyong National University)
Choi, Kang Duk (Genomic Informatics Center, Hankyong National University)
Kong, Hong Sik (Genomic Informatics Center, Hankyong National University)
Publication Information
Korean Journal of Poultry Science / v.40, no.2, 2013 , pp. 83-89 More about this Journal
Abstract
iNOS (Inducible nitric oxide synthase) and TLR-4 (Toll-like Receptor-4) play crucial roles in innate immunity of poultry. iNOS has been mapped to chicken chromosome 14 and implicated in a variety of chicken diseases. iNOS possesses potent antimicrobial activity, including the inhibition of microbes replication in vitro. TLR-4 is a pathogen associated molecular-pattern receptor for bacterial product, such as LPS (lipopolysaccharides) found in Gram negative bacteria, that triggers pro-inflammatory cytokine expression after engagement with ligands. In the previous studies, genetic analysis of iNOS and TLR-4 revealed the possible association of mutation in these genes with the intestinal microflora of cecum when infected with Salmonella spp. This study was aimed to augment previous findings, which show the association of iNOS (C14513T) and TLR-4 (G4409T) polymorphisms with economic traits in Korean Native Black (KNB), Rhode Island Red (RIR) and Cornish chickens. Investigation in the effect of SNPs on economic traits (layday, layw, layno, bw150, bw270, layw270) was conducted. iNOS (C14513T) had a significant effect on the average body weight at 270 days of age (p<0.05) in both KNB and RIR, whereas TLR-4 (G4409T) showed no significant correlation with all traits (p>0.05). The results obtained from using the candidate genes can be useful for the genetic improvement of body weight in both KNB and RIR breeds.
Keywords
chicken; Korea Native Chicken; Cornish; Rhode Island Red; iNOS; TLR-4;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Amaral AJ, Megens HJ, Crooijmans RP, Heuven HC, Groenen MA 2008 Linkage disequilibrium decay and haplotype block structure in the pig. Genetics 179:569-579.   DOI   ScienceOn
2 Gao Y, Feng CG, Song C, Du ZQ, Deng XM, Li N, Hu XX 2011 Mapping quantitative trait loci affecting chicken body size traits via genome scanning. Anim Genet 42:670-674.   DOI   ScienceOn
3 Gautier M, Faraut T, Moazami-Goudarzi K, Navratil V, Foglio M, Grohs C, Boland A, Garnier JG, Boichard D, Lathrop GM, Gut IG, Eggen A 2007 Genetic and haplotypic structure in 14 European and African cattle breeds. Genetics 177:1059-1070.   DOI   ScienceOn
4 Jayanthe RP, Rajapakse JR, Buddhika MD, Nagataki M, Nomura H, Watanabe Y, Ikeue Y, Agatsuma T 2010 Effect of Sophy ${\beta}$-glucan on immunity and growth performance in broiler chicken. J Vet Med Sci 72:1629-1632.   DOI   ScienceOn
5 Malek M, Lamont SJ 2003 Association of INOS, TRAIL, TGFbeta2, TGF-beta3, and IgL genes with response to Salmonella enteritidis in poultry. Genet Sel Evol 35:S 99-111.   DOI   ScienceOn
6 Malek M, Hasenstein JR, Lamont SJ 2004 Analysis of chicken TLR4, CD28, MIF, MD-2, and LITAF genes in a Salmonella enteritidis resource population. Poultry Sci 83: 544-549.   DOI
7 Megens HJ, Crooijmans RP, Bastiaansen JW, Kerstens HH, Coster A, Jalving R, Vereijken A, Silva P, Muir WM, Cheng HH, Hanotte O, Groenen MA 2009 Comparison of linkage disequilibrium and haplotype diversity on macroand microchromosomes in chicken. BMC Genet 10:86.
8 Tohidi R, Idris IB, Panandam JM, Bejo MH 2012 The effects of polymorphisms in IL-2, $IFN-{\gamma}$, $TGF-{\beta}2$, IgL, TLR-4, MD-2 and iNOS genes on resistance to Salmonella Enteritidis in indigenous chickens. Avian Pathol 41:605-612.   DOI
9 박준용 한동수 김보현 강은경 이영춘 이항락 김진배 손주현 최호순 강정옥 함준수 2003 Helicobacter pylori 감염증에서 위점막의 Toll-like Receptor 4 발현. 대한소화기학회지 41:171-176.   과학기술학회마을
10 서성준 노병관 신봉주 홍창권 2002 Dendric Epidermal Tcell에서 iNOS mRNA의 발현과 IL-3 생산에 NO가 미치는 영향. 대한피부과학회지 40:1225-1234.
11 이상범 김병극 박창호 박건현 김영성 강한석 김영철 김윤칠 배승철 김선구 최윤재 이홍구 2011 토종육계에 있어서 복합 생균제 및 면역증강제의 항생제 대체효과. 한국동물자원과학회지 53:409-418.