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http://dx.doi.org/10.5536/KJPS.2013.40.2.139

Genetic Variations of Chicken MC1R Gene and Associations with Feather Color of Korean Native Chicken (KNC) 'Woorimatdag'  

Park, Mi Na (Animal Genomics and Bioinformatics Division, National Institute of Animal Science, RDA)
Kim, Tae-Hun (Animal Genomics and Bioinformatics Division, National Institute of Animal Science, RDA)
Lee, Hyun-Jeong (Animal Genomics and Bioinformatics Division, National Institute of Animal Science, RDA)
Choi, Jin Ae (Animal Genomics and Bioinformatics Division, National Institute of Animal Science, RDA)
Heo, Kang-Nyeong (Poultry Science Division, National Institute of Animal Science, RDA)
Kim, Chong-Dae (Poultry Science Division, National Institute of Animal Science, RDA)
Choo, Hyo-Jun (Poultry Science Division, National Institute of Animal Science, RDA)
Han, Jae-Yong (Department of Agricultural Biotechnology, Seoul National University)
Lee, Taeheon (Department of Agricultural Biotechnology, Seoul National University)
Lee, Jun-Heon (Department of Animal Science and Biotechnology, Chungnam National University)
Lee, Kyung-Tai (Animal Genomics and Bioinformatics Division, National Institute of Animal Science, RDA)
Publication Information
Korean Journal of Poultry Science / v.40, no.2, 2013 , pp. 139-145 More about this Journal
Abstract
There are several loci controlling the feather color of birds, of which one of the most studied is Extended black (E) encoding the melanocortin 1-receptor (MC1R). Mutations in this gene affect the relative distribution of eumelanin, phaeomelanin. The association of feather color and sequence polymorphism in the melanocortin 1-receptor (MC1R) gene was investigated using Korean native chicken H breed (H_PL) and 'Woorimatdag' commercial chickens (Woorimatdag_CC). In order to correlate gene mutation to Korean native chicken feather color, single nucleotide polymorphism (SNP) from MC1R gene sequence were investigated. A total of 307 birds from H_PL and Woorimatdag_CC were used. H_PL have black, black-brown feather color and Woorimatdag_CC have black with brown spots or brown with black spots. There are 6 SNPs in MC1R gene, locus T69C, C212T, A274G, G376A, G636A, T637C. 3 SNPs are nonsynonymous that change amino acid. But it is difficult to find correlation of feather color and polymorphisms. It will be needed to increase the population of Korean native chicken H breed and correlation analysis of genetic variation with feather colors.
Keywords
Korean Native Chickens; feather color; MC1R; SNP;
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1 Benjamini Y, Hochberg Y 1995 Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B 57(1):289-300.
2 Choe JH, Nam KC, Jung S, Kim B, Yun HJ, Jo C 2010 Differences in the quality characteristics between commercial Korean native chickens and broilers. Korean J Food Sci Ani Resour 30:13-19.   과학기술학회마을   DOI   ScienceOn
3 Doucet SM, Goto RM, Auffray C, Miller MM 1993 A polymorphic system related to but genetically independent of the chicken major histocompatibility complex. Immunogenetics 37:408-414.
4 Gunnarsson U, Hellstrom AR, Tixier-Boichard M, Ninvielle F, Bed'hom B, Ito S, Jensen P, Rattink A, Vereijken A, Andersson L 2007 Mutations in SLC45A2 cause plumage color variation in chicken and Japanese quail. Genetics 175:867-877   DOI   ScienceOn
5 Jeon HJ, Choe JH, Jung Y, Kruk ZA, Lim DG, Jo C 2010 Comparison of the chemical composition, textural characteristics, and sensory properties of North and South Korean native chickens and commercial broilers. Korean J Food Sci Ani Resour 30:171-178.   과학기술학회마을   DOI   ScienceOn
6 Kerje S, Lind J, Schutz K, Jensen P, Andersson L 2003 Melanocortin 1-receptor(MC1R) mutations are associated with plumage colour in chicken. Anim Genet 34:241-248.   DOI   ScienceOn
7 Kim HK 2010 Breeding control of Woorimatdak (1). Korean Poultry Journal 487:153-155.
8 Ling MK, Lagerstrom MC, Fredriksson R, Okimoto R, Mundy NI, Takeuchi S, Schioth HB 2003 Association of feather colour with constitutively active melonocortin 1 receptor in chicken. Eur J Biochem 270:1441-1449.   DOI   ScienceOn
9 Lu D, Vage DI, Cone RD 1998 A ligandmimetic model for constitutive activation of the melanocortin 1-receptor. Mol Endocrinol 12:592-604.   DOI   ScienceOn
10 Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira M, Bender D, Maller J, Sklar P, Bakker P, Daly MJ, Sham PC 2007 PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81(3):559-575.   DOI   ScienceOn
11 Robbins LS, Nadeau JH, Johnson KR, Kelly MA, Roselli- Rehfuss L, Baack E, Mountjoy KG, Cone RD 1993 Pigmentation phenotypes of variant extension locus alleles result from point mutation that alter MSH receptor function. Cell 72:827-834.   DOI   ScienceOn
12 Saetre GP, Borge T, Lindroos K, Haavie J, Sheldon BC, Primmer C, Syvanen AC 2003 Sex chromosome evolution and speciation in Ficedula flycatchers. Proc Biol Sci 270:53-59.   DOI   ScienceOn
13 Sang BD, Kong HS, Kim HK, Choi CH, Kim SD, Cho YM, Sang BC, Lee JH, Jeon GJ, Lee HK 2006 Estimation of genetic parameters for economic traits in Korean. Asian- Aust J Anim Sci 19:319-323.   과학기술학회마을   DOI
14 Takeuchi S, Suzuki S, Hirose S, Yabuuchi M, Sato C, Yamamoto H, Takahashi S 1996a Molecular cloning and sequence analysis of the chick melanocortin 1-receptor gene. Biochim Biophys Acta 1306:122-126.   DOI   ScienceOn
15 Takeuchi S, Suzuki S, Yabuuchi M, Takahashi S 1996b A possible involvement of melanocortin 1-receptor in regulating feather colour pigmentation in the chicken. Biochim Biophys Acta 1308:164-168.   DOI   ScienceOn
16 Theron E, Hawkins K, Bermingham E, Ricklefs RE, Mundy NI 2001 The molecular basis of an avian plumage polymorphism in the wild; A melanocortin-1-receptor point mutation in perfecrly associated with the melanic plumage morph of the bananaquit, Coereba flaveola. Curr Biol 11:550-557.   DOI   ScienceOn
17 William RB III, Geoffrey EH, Christine AS 2000 Effects of coccidial and mycoplasmal infections on carotenoid-based plumage pigmentation in male house finches. The Auk 117(4):952-963.   DOI   ScienceOn
18 국립축산과학원 2008 토종닭 사육 및 인증기준 설정 연구. 가금수급안정위원회.
19 박미나 홍의철 강보석 김학규 김재홍 나승환 채현석 서옥석 한재용 정재홍 황보 종 2010 교배 조합 토종닭의 이화학적 성상 및 육질 특성. 한국가금학회지 37(4):415-421.   과학기술학회마을   DOI   ScienceOn
20 허강녕 추효준 서보영 박미나 정기철 황보 종 김학규 홍의철 서옥석 강보석 2011 토종닭과 실용계에서 TYR 및 MC1R 유전자의 변이 분석. 농업과학연구 38(3):465-471.   과학기술학회마을