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http://dx.doi.org/10.5536/KJPS.2009.36.3.207

Identification of Novel Single Nucleotide Polymorphisms on ADSL Gene Using Economic Traits in Korean Native Chicken  

Lee, J.A. (Genomic Informatics Center, Hankyong National University)
Jeon, S.A. (Genomic Informatics Center, Hankyong National University)
Oh, J.D. (Genomic Informatics Center, Hankyong National University)
Park, K.D. (Genomic Informatics Center, Hankyong National University)
Choi, K.D. (Genomic Informatics Center, Hankyong National University)
Jeon, G.J. (Genomic Informatics Center, Hankyong National University)
Lee, H.K. (Genomic Informatics Center, Hankyong National University)
Kong, H.S. (Genomic Informatics Center, Hankyong National University)
Publication Information
Korean Journal of Poultry Science / v.36, no.3, 2009 , pp. 207-213 More about this Journal
Abstract
Adenylosuccinate lyase (ADSL) deficiency is a disease of purine metabolism which affects patients both biochemicall and behaviorally. An obstacle of this purine nucleotide cycle(PNC) can be caused brain functional disorder and growth disorder. So ADSL deficiency, which is associated with sever mental retardation, autistic features and energy metabolism. This study was performed to identify SNP on ADSL gene in chicken. The nucleotides were observed as T to C ($7724^{th}$ nucleotide), C to T ($7732^{nd}$ nucleotide), G to T ($10108^{th}$ nucleotide), A to T ($10356^{th}$ nucleotide), G to A($10375^{th}$ nucleotide), A to C ($10402^{nd}$ nucleotide), A to T ($12716^{th}$ nucleotide), T to A ($12717^{th}$ nucleotide), C to T ($15491^{st}$ nucleotide), C to T ($15542^{nd}$ nucleotide) and C to T ($15550^{th}$ nucleotide). The nucleotide substitutions at $15542^{nd}$ and $15550^{th}$ (GeneBank accession no. AY665559) were found as missense mutation (alanine$\rightarrow$valine, proline$\rightarrow$serine, respectively). This study will be useful for farther researches for identifying association between these SNPs and energy metabolism in chicken. The C15550T SNP showed three genotypes, CC, CT, TT by digestion with the genotype TT had significantly faster the first lay day (150.0) than CT (162.0, P<0.05) and genotype TT (150.0, P<0.05) had significantly higher the egg production rate than CT (172.4, P<0.05). According to result of this study, a C15550T was found to have a significantly effect first lay day and mean egg production. It will be possible to use SNP marker on selecting chicken to improve important economic traits, which is the first lay day and mean egg production.
Keywords
ADSL; SNP; missense mutation; Korean native chicken;
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