[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.13160/ricns.2017.10.1.14

Binding Interaction Analysis of Neuromedin U Receptor 1 with the Native Protein Neuromedin U

Nagarajan, Santhosh Kumar (Department of Bioinformatics, School of Bioengineering, SRM University)
Madhavan, Thirumurthy (Department of Genetic Engineering, School of Bioengineering, SRM University)

Publication Information

Journal of Integrative Natural Science / v.10, no.1, 2017 , pp. 14-19 More about this Journal

Abstract

Neuromedin, a neuropeptide, which is involved in various functions that include contractile activity on smooth muscle, controlling the blood flow and ion transport in the intestine, increased blood pressure and regulation of adrenocortical function. It is involved in the pathophysiology of various immune mediated inflammatory diseases like asthma. In this study, we have performed protein-protein docking analysis of neuromedin U - neuromedin U receptor 1 complex. We have developed homology models of neuromedin U, and selected a reliable model using model validation. The model was docked with the receptor model, to analyse the crucial interactions of the complex. This study could be helpful as a tool in developing novel and potent drugs for the diseases related with neuromedin U receptor 1.

Keywords

Neuromedin U Receptor 1; GPCR; Neuromedin; NMUR1; Protein-protein Docking;

Citations & Related Records

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