[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.13160/ricns.2016.9.2.86

Biological Activity of Multifunctional Oligopeptide Derivatives

Kim, Bo Mi (Department of BionanoChemistry, Wonkwang University)

Publication Information

Journal of Integrative Natural Science / v.9, no.2, 2016 , pp. 86-93 More about this Journal

Abstract

The peptide sequences, GHK(Gly-His-Lys) and KTTKS(Lys-Thr-Thr-Lys-Ser), using a collagen stimulator recently were manipulated at N-terminal as a multifunctional peptide derivative with PEG(polyethyleneglycol) linker connected to gallic acid which presents anti-inflammatory activity. The multifunctional peptide derivatives were obtained in a normal peptide preparation method through SPPS(solid phase peptide synthesis) using Fmoc chemistry and a carboxyl group insertion reaction of PEG-3,4,5-triacetoxy benzoate by using potassium tert-butoxide and ethyl bromoacetate, which was separated by Sephadex DEAE. It gave a good compromise to a cosmetic application for cell cytotoxicity, anti-wrinkle, and anti-inflammation.

Keywords

Oligopeptide Derivative; SPPS; PEGylation; Cosmetics;

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Times Cited By KSCI : 5 (Citation Analysis)

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