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Effect of Short-term Undernutrition on Hindlimb Muscles in Rats  

Choe, Myoung-Ae (College of Nursing, Seoul National University)
Lee, Kyoung-A (Asan Medical Center)
An, Gyeong-Ju (Department of Nursing, Cheongju University)
Publication Information
Journal of Korean Biological Nursing Science / v.13, no.2, 2011 , pp. 179-184 More about this Journal
Abstract
Purpose: The purpose of this study was to examine the effect of short-term undernutrition on muscle weight and Type I and II fiber cross-sectional area of hindlimb muscles in undernourished rats. Methods: Adult male Sprague-Dawley rats were randomly assigned to one of two groups: The undernourished (UN) group (n=9) and the control (C) group (n=9). A control group was allowed to have water and pellet ad libitum for 5 days. Undernutrition was induced by providing 32% of total intake of the control group for 5 days. Body weight of two groups and food intake of the control group were measured every day. At 6 days all rats were anesthetized and soleus, plantaris and gastrocnemius muscles, and liver were dissected. Body weight, food intake, muscle weight, liver weight and cross-sectional area were determined. Results: The UN group at 6 days after undernutrition showed significant decreases, as compared to the control group in body weight, liver weight, muscle weight of soleus, plantaris, and gastrocnemius, and Type I fiber cross-sectional area of soleus and gastrocnemius muscles and Type II fiber cross-sectional area of plantaris and gastrocnemius muscles. Conclusion: Hindlimb muscle atrophy occurs from the short-term undernutrition.
Keywords
Undernutrition; Muscular atrophy; Muscle weight; Muscle fiber;
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