Browse > Article
http://dx.doi.org/10.5351/KJAS.2015.28.2.221

Gamma Mixed Model to Improve Sib-Pair Linkage Analysis  

Kim, Jeonghwan (Department of Statistics, Inha University)
Suh, Young Ju (Department of Biomedical Sciences, College of Medicine, Inha University)
Won, Sungho (Department of Public Health Science, Seoul National University)
Nah, Jeung Weon (Department of Biostatistics, College of Medicine, Korea University)
Lee, Woojoo (Department of Statistics, Inha University)
Publication Information
The Korean Journal of Applied Statistics / v.28, no.2, 2015 , pp. 221-230 More about this Journal
Abstract
Traditionally, sib-pair linkage analysis with repeated measures has employed linear mixed models, but it suffers from the lack of power to find genetic marker loci associated with a phenotype of interest. In this paper, we use a gamma mixed model to improve sib-pair linkage analysis and compare it with a linear mixed model in terms of power and Type I error. We illustrate that the use of gamma mixed model can achieve higher power than linear mixed model with Genetic Analysis Workshop 13 data.
Keywords
Linkage analysis; gamma mixed model; identity link; hierarchical generalized linear model;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Almasy, L., Amos, C. I., Bailey-Wilson, J. E., Cantor, R. M., Jaquish, C. E., Martinez, M., Neuman, R. J., Olson, J. M., Palmer, L. J., Rich, S. S., Spence, M. A. and MacCluer, J. W. (2003). Genetic analysis workshop 13: Analysis of longitudinal family data for complex diseases and related risk factors, BMC Genetics, 4(Supple 1), S1.   DOI
2 Almasy, L. and Blangero, J. (1998). Multipoint quantitative-trait linkage analysis in general pedigrees, American Journal of Human Genetics, 62, 1198-1211.   DOI   ScienceOn
3 Barber, M. J., Cordell, H. J., MacGregor, A. J. and Andrew, T. (2004). Gamma regression improves Haseman-Elston and Variance Components Linkage Analysis for Sib-Pairs, Genetic Epidemiology, 26, 97-107.   DOI   ScienceOn
4 Breslow, N. E. and Clayton, D. (1993). Approximate inference in generalized linear mixed models, Journal of the American Statistical Association, 88, 9-25.
5 Haseman, J. K. and Elston, R. C. (9172). The investigation of linkage between a quantitative trait and a marker locus, Behavior Genetics, 2, 3-19.   DOI
6 Kruglyak, L. and Lander, E. (1995). Complete multipoint sib-pair analysis of qualitative and quantitative traits, American Journal of Human Genetics, 57, 439-454.
7 Lee, Y., Nelder, J. A. and Pawitan, Y. (2006). Generalized Linear Models with Random Effects: Unified Analysis via h-Likelihood, Chapman and Hall/CRC.
8 Suh, Y., Park, T. and Cheong, S. (2003). Linkage analysis of longitudinal data, BMC Genetics, 4(Suppl I):S27.   DOI   ScienceOn
9 Won, S., Elston, R. C. and Park, T. (2006). Extension of the Haseman-Elston regression model to longitudinal data, Human Heredity, 61, 111-119.   DOI   ScienceOn