Browse > Article
http://dx.doi.org/10.5351/KJAS.2009.22.5.1033

Parametric Sequential Test Procedure to Find the Minimum Effective Dose  

Park, Su-Jin (Department of Biostatistics, The Catholic University of Korea)
Kim, Dong-Jae (Department of Biostatistics, The Catholic University of Korea)
Publication Information
The Korean Journal of Applied Statistics / v.22, no.5, 2009 , pp. 1033-1046 More about this Journal
Abstract
In new drug development studies or clinical trials, zero-dose control is needed in general to determine the lowest dose level for a new drug which can act with our bodies. When the lowest dose level compared with zero-dose control has significant difference in effect, it is referred as minimum effective dose(MED). We propose, in this paper, parametric sequential test using updated control to identify the minimum effective dose(MED) level. Monte Carlo Simulation is adapted to examine the power and experimental significance levels of the proposed method with other methods.
Keywords
Minimum effective dose; sequential test; updated control;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kim, D. and Wolfe, D. A (1995). Distribution-free partially sequential tests for treatments versus control setting, Biometrical Journal, 37, 259-271   DOI   ScienceOn
2 Lan, K. K. G. and DeMets, D. L. (1983). Discrete sequential boundaries for clinical trials, Biometrika, 70, 659-663   DOI
3 Nakamura, T. and Douke, H. (2007). Development of sequential multiple comparison procedure for dose response test, Biometrical Journal, 49, 30-39   DOI   ScienceOn
4 Ruberg, S. J. (1989). Contrasts for identifying the minimum effective dose, Journal of the American Statistical Association, 84, 816-822   DOI   ScienceOn
5 Terpstra, T. J. (1952). The asymptotic normality and consistency of Kendall's test against trend, When ties are present in one ranking, Indagatione Mathecaticae, 14, 327-333
6 Wolfe, D. A. (1977). Two-stage two-sample median test, Technometrics, 19, 495-501   DOI   ScienceOn