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http://dx.doi.org/10.5351/KJAS.2009.22.4.793

An Approximate Unconditional Test of Non-Inferiority for Two Proportions Based on Odds Ratio  

Seo, Young-Yeol (Department of Biostatistics, The Catholic University of Korea)
Kim, Dong-Jae (Department of Biostatistics, The Catholic University of Korea)
Publication Information
The Korean Journal of Applied Statistics / v.22, no.4, 2009 , pp. 793-804 More about this Journal
Abstract
The hypotheses of difference, ratio and odds ratio between two proportions are used for the non-inferiority trial. The approximate unconditional test suggested by Kang and Chen (2000) based on difference and ratio have the potential problem against the failure rate. When the sample size is small, the type I errors of the asymptotic test using the normal approximation suggested by Chen et al. (2000) tends to exceed the nominal level. Therefore, we propose the approximate unconditional test based on odds ratio and compare the test with the asymptotic test. And we compare the three hypotheses used in the approximate unconditional tests of two proportions with respect to the type I errors and power.
Keywords
Non-inferiority; two-proportions; an approximate unconditional test; odds ratio;
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  • Reference
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