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http://dx.doi.org/10.5351/KJAS.2008.21.1.053

Main SNP Identification of Hanwoo Carcass Weight with Multifactor Dimensionality Reduction(MDR) Method  

Lee, Jea-Young (Dept. of Statistics, Yeungnam University)
Kim, Dong-Chul (Graduate,Dept. of Statistics, Yeungnam University)
Publication Information
The Korean Journal of Applied Statistics / v.21, no.1, 2008 , pp. 53-63 More about this Journal
Abstract
It is commonly believed that disease of human or economic traits of livestock are caused not by single gene acting alone, but by multiple genes interacting with one an-other. This issue is difficult due to the limitations of parametric statistical method like as logistic regression for detection of gene effects that are dependent solely on interactions with other genes and with environmental exposures. Multifactor dimensionality reduction (MDR) nonparametric statistical method, to improve the identification of single nucleotide polymorphism (SNP) associated with the Hanwoo(Korean cattle) carcass cold weight, is applied and compared with ANOVA results.
Keywords
Single nucleotide polymorphism(SNP); multifactor dimensionality reduction(MDR); carcass cold weight; AVOVA; CART(classification and regression trees);
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1 Bastione, L., Reilly, M., Rader, D. J. and Foulkes, A. S. (2004). MDR and PRP: A comparison of methods for high-order genotype-phenotype associations, Human Geredity, 58, 82-92   DOI   ScienceOn
2 Chung, Y. J., Lee, S. Y., Park, T. S. (2005). Multifactor dimensionality reduction in the presence of missing observations, In Proceedings of the Autumn Conference, The Korea Statistical Society, 31-36
3 Ritchie, M. D., Hahn, L. W. and Moore, J. H. (2003). Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity, Genetic Epidemiology, 24, 150-157   DOI   ScienceOn
4 Hosmer, D. W. and Lemeshow, S. (2000). Applied Logistic Regression, 2nd ed., John Wiley & Sons, New York
5 Kim, J. W, Park, S. I. and Yeo, J. S. (2003). Linkage mapping and QTL on chromosome 6 in Hanwoo (Korean Cattle), Asian-Australasian Journal of Animal Sciences, 16, 1402-1405   DOI
6 Barendse, W., Bunch, R., Thomas, M., Armitage, S., Baud, S. and Donaldson, N. (2004). The TG5 thyroglobulin gene test for a marbling quantitative trait loci evaluated in feedlot cattle, Australian Journal of Experimental Agriculture, 44, 669-674   DOI   ScienceOn
7 Ritchie, M. D., Hahn, L. W., Roodi, N., Bailey, L. R., Dupont, W. D., Parl F. F. and Moore, J. H. (2001). Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer, American Journal of Human Genetics, 69, 138-147   DOI   ScienceOn
8 Hahn, L. W., Ritchie, M. D. and Moore, J. H. (2003). Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions, Bioinformatics, 19, 376-382   DOI   ScienceOn
9 Page, B. T., Casas, E., Quaas, R. L., Thallman, R. M., Wheeler, T. L., Shackelford, S. D., Koohmaraie, M., White, S. N., Bennett, G. L., Keele, J. W., Dikeman, M. E. and Smith, T. P. L. (2004). Association of markers in the bovine CAPNI gene with meat tenderness in large crossbred populations that sample influential industry sires, Journal of Animal Science, 82, 3474-3481
10 Lee, Y. S., Bae, J. H., Lee, J. Y., Park, H. S. and Yeo, J. S. (2007). Identification of candidate SNP for economic traits on chromosome 6 in Korean cattle, Animal Genetics, submitted
11 Snelling, W. M., Casas, E., Stone, R. T., Keele, J. W., Harhay, G. P., Bennett, G. L. and Smith, T. P. L. (2005). Linkage mapping bovine EST-based SNP, BMC Genomics, 6,74-84   DOI   ScienceOn