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http://dx.doi.org/10.5351/KJAS.2003.16.2.195

Estimation of Haplotype Proportions in Single Necleotide Polymorphism Group Using EM Algorithm  

김선우 (삼성생명과학연구소, 통계지원팀)
김종원 (성균관대학교 의과대학, 삼성의료원, 진단검사의학과)
이경아 (고려대학교 의과대학, 고려대학교 안암병원, 진단검사의학과)
Publication Information
The Korean Journal of Applied Statistics / v.16, no.2, 2003 , pp. 195-202 More about this Journal
Abstract
Haplotype analysis in SNP is very useful for the study of complex genetic disease due to low cost and high efficiency comparing to individual analysis of each SNP, and is functionally important in biological view. But, the gametic phase of haplotypes is usually unknown in SNP group, and it is difficult to predict haplotype proportions. In this study, haplotype proportions were estimated using EM algorithm from diploid data of SNP group in solid tumor group and normal group. From these results, linkage disequilibrium among SNPs was analyzed.
Keywords
Single nucleotide polymorphism; diploid; haplotype; EM algorithm; linkage disequilibrium;
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