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http://dx.doi.org/10.5351/KJAS.2002.15.2.323

Investigation on the modified continual reassessment method in phase I clinical trial  

강승호 (이화여자대학교 통계학과)
Publication Information
The Korean Journal of Applied Statistics / v.15, no.2, 2002 , pp. 323-336 More about this Journal
Abstract
In this paper we consider the modified continual reassessment method in which a cohort consists of three patients. Simulation has been a main research tool in the investigation of CRM. In this paper we propose complete enumeration as an alternative of simulation. Using new method we show that the expected toxicity rate at the MTD converges to the target toxicity rate well as the sample size increases.
Keywords
exact distribution; new dug development; Bayesian statistics;
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Times Cited By KSCI : 8  (Citation Analysis)
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