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http://dx.doi.org/10.5351/CKSS.2010.17.2.231

Comparative Study for Estimating Vaccine Efficacy in Vaccine Research under Heterogeneity  

Lee, Soo-Young (Department of Statistics, Korea University)
Lee, Jae-Won (Department of Statistics, Korea University)
Publication Information
Communications for Statistical Applications and Methods / v.17, no.2, 2010 , pp. 231-239 More about this Journal
Abstract
In vaccine research, proportional hazards model including only first event have been widely used for estimating vaccine efficacy because it is easy to interpret and convenient. However, this method causes not only loss of information but also biased result when heterogeneity of study subject in exposure and susceptibility exists. Furthermore, it is hard to ignore the possibility that each event is correlated with each other in the repeated events. Therefore, we compare various statistical models to estimate vaccine efficacy under various situations with heterogeneity and event dependency.
Keywords
Vaccine efficacy; repeated event; heterogeneity; survival analysis;
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