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http://dx.doi.org/10.5351/CKSS.2004.11.3.597

Nonparametric Procedure for Identifying the Minimum Effective Dose with Ordinal Response Data  

Kang, Jongsook (Department of Biostatistics, The Catholic University of Korea)
Kim, Dongjae (Department of Biostatistics, The Catholic University of Korea)
Publication Information
Communications for Statistical Applications and Methods / v.11, no.3, 2004 , pp. 597-607 More about this Journal
Abstract
The primary interest of drug development studies is identifying the lowest dose level producing a desirable effect over that of the zero-dose control, which is referred as the minimum effective dose (MED). In this paper, we suggest a nonparametric procedure for identifying the MED with binary or ordered categorical response data. Proposed test and Williams' test are compared by Monte Carlo simulation study and discussed.
Keywords
Binary response; Minimum effective dose (MED); Nonparametric test; Monte Carlo study; Ordinal response;
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