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http://dx.doi.org/10.7317/pk.2015.39.3.480

Thermosensitive Chitosan-based Hydrogel with Growth Factor as Adhesion Barrier  

Park, Jun-Kyu (Bioalpha Co. Ltd.)
Nah, Jae-Woon (Department of Polymer Science and Engineering, Sunchon National University)
Choi, Changyong (Department of Polymer Science and Engineering, Sunchon National University)
Publication Information
Polymer(Korea) / v.39, no.3, 2015 , pp. 480-486 More about this Journal
Abstract
The adhesion of tissue and organ occur with frequency after surgery. Theomosensitive hydrogel was prepared from poloxamer/chitosan/epidermal growth factor as adhesion barrier agent. The prepared hydrogel showed sol-gel transition temperatures around human temperature and gelation temperature was the faster within 1 min. The hydrogel sustained the release of epidermal grow factor during 7 days. The hydrogel was highly effective for the prevention of tissue and organ adhesion in rat model. The thermosensitive and antibacterial chitosan hydrogel can be useful to consider the anti-adhesion barrier with increased adhesion of organ and sustained release of epidermal growth factor.
Keywords
poloxamer; chitosan; tissue anti-adhesion; hydrogel; epidermal growth factor;
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