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http://dx.doi.org/10.7317/pk.2015.39.1.40

Blood-compatible Bio-inspired Surface of Poly(L-lactide-co-ε-caprolactone) Films Prepared Using Poor Co-solvent Casting  

Lim, Jin Ik (Laboratory of Biointerfaces/Tissue Engineering, Department of Chemical Engineering, Institute of Tissue Regeneration Engineering, College of Engineering, Dankook University)
Kim, Soo Hyun (Division of Life and Health Sciences, Biomaterials Research Center, Korea Institute of Science and Technology)
Publication Information
Polymer(Korea) / v.39, no.1, 2015 , pp. 40-45 More about this Journal
Abstract
Simple poor-cosolvent casting was used to surface treat biodegradable elastic poly(L-lactide-co-${\varepsilon}$-caprolactone) (PLCL; 50:50) copolymer films that presented lotus-leaf-like structures. We evaluated whether the lotus-leaflike-structured PLCL (L-PLCL) films could be used as a biomaterial for artificial vascular grafts. The surface morphology, hydrophobicity, and antithrombotic efficiency of the films were examined while immersed in platelet-rich plasma (PRP) using scanning electron microscopy (SEM) and a contact angle meter. The recovery and crystallinity of the films were measured using a tensile-strength testing machine and an X-ray diffractometer, respectively. The solvent containing acetic acid, as a poor co-solvent, and methylene chloride mixed in a 1:2 ratio produced an optimal PLCL film with a water contact angle of approximately $124^{\circ}$. Furthermore, the surface of the L-PLCL films immersed in PRP showed a lower rate of platelet adhesion (<10%) than that of the surface of an untreated PLCL film immersed in PRP.
Keywords
antithrombotic material; lotus-leaf-like structure; co-solvent system; blood vessel; surface modification;
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