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http://dx.doi.org/10.7317/pk.2014.38.5.676

Development of Porous Cellulose Hydrogel for Enhanced Transdermal Delivery of Liquiritin and Liquiritigenin as Licorice Flavonoids  

Kim, Su Ji (Department of Fine Chemistry, Cosmetic R&D Center, College of Energy and Biotechnology, Soeul National University of Science and Technology)
Kwon, Soon Sik (Department of Fine Chemistry, Cosmetic R&D Center, College of Energy and Biotechnology, Soeul National University of Science and Technology)
Yu, Eun Ryeong (Department of Fine Chemistry, Cosmetic R&D Center, College of Energy and Biotechnology, Soeul National University of Science and Technology)
Park, Soo Nam (Department of Fine Chemistry, Cosmetic R&D Center, College of Energy and Biotechnology, Soeul National University of Science and Technology)
Publication Information
Polymer(Korea) / v.38, no.5, 2014 , pp. 676-681 More about this Journal
Abstract
Licorice, widely used as a herbal medicine, has flavonoids such as liquiritin and its aglycone, liquiritigenin that show anti-oxidant and anti-inflammatory properties. Licorice flavonoid-loaded cellulose hydrogels were prepared as carriers for skin drug delivery, and their properties were investigated. The porous cellulose hydrogel was made by reacting cellulose with epichlorohydrin as a cross-linking agent in NaOH/urea(1~10%) solutions. Through studies on the rheological properties and water uptake of the hydrogel, a NaOH/urea(6%) solution was established as being optimum for the synthesis of the cellulose hydrogel containing liquiritin and liquiritigenin. Scanning electron microscopy (SEM) observations of a cross-section of the prepared hydrogel indicated its porosity. In particular, in skin permeation experiments using a Franz diffusion cell, hydrogel containing the licorice flavonoids showed remarkable transdermal permeation compared to the control group. These results indicate that porous cellulose hydrogel is a potential drug delivery system to enhance the skin permeation of licorice flavonoids.
Keywords
liquiritin; liquiritigenin; cellulose; hydrogel; drug delivery system;
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Times Cited By KSCI : 3  (Citation Analysis)
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