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http://dx.doi.org/10.7317/pk.2014.38.3.333

Drug Adsorption Behavior of Polyolefin Infusion Tube Compared to PVC and PU  

Park, Kang Hoon (Department of Polymer Science & Engineering, Sungkyunkwan University)
Park, Chang Kyu (Polyscientech Co., Ltd.)
Park, Jong (Polyscientech Co., Ltd.)
Jeon, Seungho (Polyscientech Co., Ltd.)
Bang, Sa-Ik (Department of Plastic Surgery, Samsung Medical Center)
Kim, Ji-Heung (Department of Chemical Engineering, Sungkyunkwan University)
Chung, Dong June (Department of Polymer Science & Engineering, Sungkyunkwan University)
Publication Information
Polymer(Korea) / v.38, no.3, 2014 , pp. 333-337 More about this Journal
Abstract
PVC (polyvinyl chloride) intravenous fluid bags and tubes that contain DEHP (diethylhexyl phthalate) as a plasticizer have several associated disadvantages for intravenous injections. We investigated the drug absorption behaviors on the inner surface of an infusion tube that consisted of commercialized PVC/PU (polyurethane). We developed a non-PVC (polyolefin) tube in order to improve the efficacy of this drug administration method. We prepared four types of non-PVC (polyolefin) infusion tubes using a polyethylene (PE), polypropylene (PP), syndiotactic 1,2-polybutadiene (PB), and styrene-ethylene (SE) copolymer elastomers were prepared using a single screw extruder. The four types of manufactured non-PVC (polyolefin) infusion tubes had good mechanical properties that were equivalent to PVC tube properties. The four types of prepared non-PVC (polyolefin) infusion tubes also prohibited drug absorption when compared to the commercialized PVC and PU tubes. Therefore, based on the results of this study, prepared non-PVC (polyolefin) tubes are good candidates for infusion because they prevent drug absorption and the release of DEHP.
Keywords
non-PVC; polyolefin; infusion tube; drug absorption; partition coefficient;
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