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http://dx.doi.org/10.7317/pk.2014.38.2.164

Comparison between Poly(lactic-co-glycolic acid) Films Contained Natural Polymers on Adhesion and Proliferation of Schwann Cells  

Ko, Hyun Ah (Dept. of BIN Fusion Tech., and Dept. of Polymer-Nano Sci. & Tech. and Polymer BIN Research Center, Chonbuk National University)
Jang, Ji Eun (Dept. of BIN Fusion Tech., and Dept. of Polymer-Nano Sci. & Tech. and Polymer BIN Research Center, Chonbuk National University)
Kim, Hyeongseok (Dept. of BIN Fusion Tech., and Dept. of Polymer-Nano Sci. & Tech. and Polymer BIN Research Center, Chonbuk National University)
Park, Chan Hum (Dept. of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University)
Kwon, Soon Yong (Dept. of Orthopedic Surgery, Yeouido St. Mary's Hospital, Catholic University of Korea)
Chung, Jin Wha (Dept. of Orthopedic Surgery, Yeouido St. Mary's Hospital, Catholic University of Korea)
Khang, Gilson (Dept. of BIN Fusion Tech., and Dept. of Polymer-Nano Sci. & Tech. and Polymer BIN Research Center, Chonbuk National University)
Publication Information
Polymer(Korea) / v.38, no.2, 2014 , pp. 164-170 More about this Journal
Abstract
This study was designed to find an appropriate biomaterial to proliferate Schwann cell (SC). Poly(lactic-co-glycolic acid) (PLGA) films mixed with demineralized bone particle (DBP), small intestine submucosa (SIS), and silk were fabricated by a solvent casting method. Analysis of MTT, SEM and RT-PCR were performed to confirm adhesion and proliferation of SC. Contact angle of films was assayed for hydrophilicity of films. We confirmed that PLGA/DBP 20% film showed higher hydrophilicity, promoted adhesion and proliferation of SC than other films. It was concluded that PLGA/DBP film can be applied for the scaffold biomaterials for the regeneration of central nerve system.
Keywords
schwann cell; demineralized bone particle (DBP); small intestine submucosa (SIS); silk; PLGA hybridized film;
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