Browse > Article
http://dx.doi.org/10.7317/pk.2014.38.2.156

Inflammatory Responses to Hydroxyapatite/Poly(lactic-co-glycolic acid) Scaffolds with Variation of Compositions  

Jang, Ji Eun (Dept. of BIN Fusion Tech., and Dept. of Polymer-Nano Sci. & Tech. and Polymer BIN Research Center, Chonbuk National University)
Kim, Hye Min (Dept. of BIN Fusion Tech., and Dept. of Polymer-Nano Sci. & Tech. and Polymer BIN Research Center, Chonbuk National University)
Kim, Hyeongseok (Dept. of BIN Fusion Tech., and Dept. of Polymer-Nano Sci. & Tech. and Polymer BIN Research Center, Chonbuk National University)
Jeon, Dae Yeon (Dept. of BIN Fusion Tech., and Dept. of Polymer-Nano Sci. & Tech. and Polymer BIN Research Center, Chonbuk National University)
Park, Chan Hum (Dept. of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University)
Kwon, Soon Yong (Dept. of Orthopedic Surgery, Yeouido St. Mary's Hospital, Catholic University of Korea)
Chung, Jin Wha (Dept. of Orthopedic Surgery, Yeouido St. Mary's Hospital, Catholic University of Korea)
Khang, Gilson (Dept. of BIN Fusion Tech., and Dept. of Polymer-Nano Sci. & Tech. and Polymer BIN Research Center, Chonbuk National University)
Publication Information
Polymer(Korea) / v.38, no.2, 2014 , pp. 156-163 More about this Journal
Abstract
Hydroxyapatite has osteoconductivity, biocompatibility and noninflammatory, and it has been used clinically as artificial bone. In this study, we prepared hydroxyapatite/poly(lactic-co-glycolic acid) (PLGA) scaffolds using 0, 10, 20, 40 and 60 wt% of hydroxyapatite. We analyzed compressive strength, SEM analysis and FTIR for mechanical property of 3D hydroxyapatite/PLGA scaffolds. For biocompatibility tests, cell proliferation and viability were measured via MTT assay and SEM. We analyzed RT-PCR, FACS, histology (H&E, ED-1) for anti-inflammatory effect. This study showed that hydroxyapatite hybrid scaffolds have low inflammatory reaction compared with the PLGA. This result has a potential for the application of artificial bone graft material.
Keywords
hydroxyapatite; inflammatory reaction; scaffold; artificial bone;
Citations & Related Records
연도 인용수 순위
  • Reference
1 C. Liu, Z. Xia, and J. T. Czernuszka, IChemE, 85, 1051 (2007).   DOI   ScienceOn
2 Q. Ye, K. Ohsaki, K. Li, D.-J. Li, C.-S. Zhu, T. Ogawa, S. Tenshin, and T. Takano-Yamamoto, Auris Nasus Larynx, 28, 131 (2001).   DOI
3 P. T. Thevenot, A. M. Nair, J. Shen, P. Lotfi, C.-Y. Ko, and L. Tang, Biomaterials, 31, 3997 (2010).   DOI
4 L. R. Buckner, M. E. Lewis, S. J. Greene, A. J. Q. Timothy, and P. Foster, Cytokine, 63, 151 (2013).   DOI
5 Y. Woo and K. Na, Int. J. Tissue Regen., 3, 63 (2012).
6 T. H. Kim, J. H. Ko, S. J. Kim, and Y. H. Park, Int. J. Tissue Regen., 2, 1 (2011).
7 S. R. Caliari, M. A. Ramirez, and B. A. C. Harley, Biomaterials, 32, 8990 (2011).   DOI
8 D. H. Yang, H. N. Park, J. B. Lee, D. N. Heo, M. S. Bae, and I. K. Kwon, Int. J. Tissue Regen., 2, 125 (2011).
9 Y. Yang, Y. Zhao, G. Tang, H. Li, X. Yuan, and Y. Fan, Polym. Degrad. Stabil., 93, 1838 (2008).   DOI   ScienceOn
10 M. S. Kim, H. H. Ahn, Y. N. Shin, M. H. Cho, G. Khang, and H. B. Lee, Biomaterials, 28, 5137 (2007).   DOI   ScienceOn
11 M. H. Fathi, A. Hanifi, and V. Mortazavi, J. Mech. Sci. Tech., 202, 536 (2008).
12 T. Koshino, T. Murase, T. Takagi, and T. Saito, Biomaterials, 22, 1579 (2001).   DOI   ScienceOn
13 C. Chang, N. Peng, M. He, Y. Teramoto, Y. Nishio, and L. Zhang, Carbohydr. Polym., 91, 7 (2013).   DOI
14 Y. K. Ko, S. H. Kim, J. S. Jeong, H. J. Ha, S. J. Yoon, J. M. Rhee, M. S. Kim, H. B. Lee, and G. Khang, Polymer(Korea), 31, 14 (2007).
15 S. J. Kim, H. H. Hong, S. H. Kim, H. L. Kim, S. H. Kim, and G. Khang, Polymer(Korea), 34, 63 (2010).
16 S. Lee, B. Lee, H. Kim, S. Kim, and Y. G. Eom, J. Korean Wood Sci. & Tech., 37, 310 (2009).
17 H. Chen, W. Yang, H. Chen, L. Liu, F. Gao, X. Yang, Q. Jiang, Q. Zhang, and Y. Wang, Colloid Surface B, 73, 212 (2009).   DOI
18 C. W. Lee, S. G. Kim, J. Y. Choi, B. D. Choi, C. S. Bae, S. J. Jeong, and M. J. Jeong, Korean J. Electron Microscopy, 35, 121 (2005).
19 S. D. Nath, S. Son, A. Sadiasa, Y. K. Min, and B. T. Lee, Int. J. Pharm., 443, 87 (2013).   DOI
20 C. C. Wu, S. T. Huang, T. W. Tseng, Q. L. Rao, and H. C. Lin, J. Mol. Struct., 979, 72 (2010).   DOI
21 Y. Song, H. Yoo, S. Eum, O. Y. Kim, S. C. Yoo, H. E. Kim, D. Lee, and G. Khang, Polymer(Korea), 35, 189 (2011).
22 Z.-L. Mou, L.-J. Zhao, Q.-A. Zhang, J. Zhang, and Z.-Q. Zhang, J. Supercrit. Fluids, 58, 398 (2011).   DOI
23 W. Qin, J. Feng, Y. Li, Z. Lin, and B. Shen, Mol. Immunol., 44, 2355 (2007).   DOI
24 D. K. Kahlon, T. A. Lansdell, J. S. Fisk, and J. J. Tepe, Bioorg. Med. Chem., 17, 3093 (2009).   DOI
25 S. C. Neves, L. S. M. Teixeira, L. Moroni, R. L. Reis, C. A. V. Blitterswijk, N. M. Alves, M. Karperien, and J. F. Mano, Biomaterials, 32, 1068 (2011).   DOI
26 M. C. Chang and J. Tanaka, Biomaterials, 23, 4811 (2002).   DOI   ScienceOn
27 R. E. Heravi, F. Hadizadeh, M. Sankian, J. T. Afshari, S. M. Taghdisi, H. Jafarian, and J. Behravan, Eur. J. Pharm. Sci., 44, 479 (2011).   DOI
28 Y. Zhang, C. Wu, T. Luo, S. Li, X. Cheng, and R. J. Miron, Bone, 51, 704 (2012).   DOI
29 R. M. Boehler, S. Shin, A. G. Fast, R. M. Gower, and L. D. Shea, Biomaterials, 34, 5431 (2013).   DOI