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http://dx.doi.org/10.7317/pk.2013.37.6.802

Development of Aloin Loaded PVA/CMC Hydrogel for Wound Healing  

Kim, Jin (Department of Advanced Chemicals and Engineering, Chonnam National University)
Lee, Chang Moon (Department of Biomedical and Engineering, Chonnam National University)
Kim, Dong-Woon (Department of Clinical Pathology, Gwangyang Health College)
Lee, Ki-Young (Korea Faculty of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University)
Publication Information
Polymer(Korea) / v.37, no.6, 2013 , pp. 802-808 More about this Journal
Abstract
The purpose of this study was to develop an aloin-loaded wound dressing with an enhanced healing effect. The cross-linked hydrogel films were prepared with poly(vinyl alcohol) (PVA) and carboxyl methyl cellulose (CMC) using a freeze-thawing (F-T) method. Their gel properties, release of drug, in vivo wound healing effect and histopathology were then evaluated. In the wound healing test, this aloin loaded PVA/CMC hydrogel showed faster healing of the wound made in rat dorsum than the aloin carbomer 934 gel or the control (carbomer 934 gel) due to phytochemical activity of aloin and moisture of CMC. In conclusion, the aloin-loaded wound dressing composed of 5% PVA, 5% CMC and 0.125% aloin is a potential wound dressing with enhanced wound healing effect.
Keywords
aloin; poly(vinyl alcohol) (PVA); carboxyl methyl cellulose (CMC); wound heal;
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