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http://dx.doi.org/10.7317/pk.2013.37.5.663

Effects of Polymers on the Cocrystallization of Adefovir Dipivoxil and Suberic Acid  

Jung, Sungyup (Department of Chemical Engineering, Soongsil University)
Kim, Il Won (Department of Chemical Engineering, Soongsil University)
Publication Information
Polymer(Korea) / v.37, no.5, 2013 , pp. 663-668 More about this Journal
Abstract
The effects of polymers on the cocrystallization of adefovir dipivoxil (AD) and suberic acid (SUB) were investigated. The polymeric additives in the present study were poly(ethylene glycol) (PEG) and poly(acrylic acid) (PAA). When the polymers were added to the solution of AD and SUB, their effects were limited to the morphology and crystallinity of the AD/SUB cocrystal, which could be also achieved without polymeric additives by the excess amount of SUB in the solution or through the solvent-assisted grinding. When the polymers were mixed with AD before adding SUB in the solution, PEG was dramatically more effective at the same amount with possible alteration of the cocrystal structure. Also, PAA completely inhibited the formation of crystals. The present study demonstrated that the effects of polymers on the cocrystallization could be tuned by simply modifying the mixing strategy.
Keywords
cocrystallization; adefovir dipivoxil; polymeric additives; growth from solutions;
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