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http://dx.doi.org/10.7317/pk.2013.37.4.462

Development of Hydrogel Containing Catechin for Wound Dressing  

Kim, Jin (Department of Advanced Chemicals and Engineering, Chonnam National University)
Cho, Eun Bi (Department of Advanced Chemicals and Engineering, Chonnam National University)
Lee, Ki-Young (Faculty of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University)
Publication Information
Polymer(Korea) / v.37, no.4, 2013 , pp. 462-469 More about this Journal
Abstract
Catechin (CTEC) is well-known as a very powerful antioxidant, containing the effects of anti-inflammation and skin wound healing. In this study, CTEC/${\beta}$-cyclodextrin (${\beta}$-CD) nanoparticles were incorporated into poly(vinyl alcohol) (PVA)/pectin (PT) hydrogel. The composite was designed for the induction of re-epithelializaton in skin wound. CTEC/${\beta}$-CD nanoparticles were prepared by a molecular complex method. The size of the CTEC nanoparticles formed in the hydrogel was in the range of $250{\pm}17.5$ nm. The incorporation efficiency of CTEC in the nanoparticles was 74%. The cumulative amounts of CTEC released from the hydrogel containing CTEC nanoparticles in the buffers of pH7.4 and 5.5 were $86.51{\pm}3.14%$ and $35.95{\pm}2.14%$ of total CTEC loaded in the hydrogel within 72 h, respectively. Also, in the wound healing test, the CTEC nanoparticles-loaded PVA/PT hydrogel showed faster healing of the wound made in rat dorsum than the CTEC gel.
Keywords
catechin; herbal medicine; transdermal delivery; re-epithelialization;
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